H S van Monsjou1, M Schaapveld2, M W M van den Brekel3, A J M Balm3. 1. Department of Otorhinolaryngology, Leiden University Medical Center, Leiden, The Netherlands; Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. Electronic address: h.s.van_monsjou@lumc.nl. 2. Department of Psychosocial Research, Epidemiology and Biostatistics, The Netherlands Cancer Institute/Antoni van Leeuwenhoek, Amsterdam, The Netherlands; Comprehensive Cancer Center Netherlands, Amsterdam, The Netherlands. 3. Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands; Department of Oral-, Maxillofacial Surgery, Academic Medical Center Amsterdam, The Netherlands.
Abstract
BACKGROUND: Several recent studies have shown that incidence of oropharyngeal carcinomas is rising in the Western World. This increase has been attributed to changes in the etiology of oropharyngeal carcinomas with a growing role for infections with Human Papilloma viruses. This nationwide study evaluates and compares trends in incidence, clinical behavior and tumor characteristics of oropharyngeal and oral squamous cell cancer. METHODS: This study comprised all 16,480 patients with primary squamous cell carcinoma of the oral tongue (OTSCC), oral cavity excluding oral tongue (OCSCC), and oropharynx (OPSCC) diagnosed from 1989 through 2008 in The Netherlands. We assessed trends in age-standardized incidence, second cancer risk and subsite specific relative survival (RS) over time. RESULTS: Incidence of OTSCC and OPSCC in males and incidence of all subsites in females increased significantly from 1989 through 2008. In males increases in incidence were largely restricted to the 50-64 year age group (estimated annual percentage change 2.2% and 3.2% for OTSCC and OPSCC, respectively), while in females incidence increased for most age groups. The incidence of OCSCC (excl. oral tongue) and OPSCC before 50 years of age decreased. Patients with OPSCC showed the poorest prognosis with a relative survival of 41.6% after 5 years and 29.4% after 10 years (P<0.001) over the entire period 1989-2008. However survival increased substantially for OPSCC patients over time (5-year RS of 37.2% in 1989-1993 to 47.6% in 2004-2008, P<0.001). CONCLUSION: Although incidence of OPSCC did increase since 1989, especially in females, similar increases were seen for OCSCC (excl. oral tongue) and OTSCC. Our study does not appear to support that HPV is the main contributor to a rising incidence of OPSCC as the effects of changes in smoking and alcohol use cannot be discounted.
BACKGROUND: Several recent studies have shown that incidence of oropharyngeal carcinomas is rising in the Western World. This increase has been attributed to changes in the etiology of oropharyngeal carcinomas with a growing role for infections with HumanPapilloma viruses. This nationwide study evaluates and compares trends in incidence, clinical behavior and tumor characteristics of oropharyngeal and oral squamous cell cancer. METHODS: This study comprised all 16,480 patients with primary squamous cell carcinoma of the oral tongue (OTSCC), oral cavity excluding oral tongue (OCSCC), and oropharynx (OPSCC) diagnosed from 1989 through 2008 in The Netherlands. We assessed trends in age-standardized incidence, second cancer risk and subsite specific relative survival (RS) over time. RESULTS: Incidence of OTSCC and OPSCC in males and incidence of all subsites in females increased significantly from 1989 through 2008. In males increases in incidence were largely restricted to the 50-64 year age group (estimated annual percentage change 2.2% and 3.2% for OTSCC and OPSCC, respectively), while in females incidence increased for most age groups. The incidence of OCSCC (excl. oral tongue) and OPSCC before 50 years of age decreased. Patients with OPSCC showed the poorest prognosis with a relative survival of 41.6% after 5 years and 29.4% after 10 years (P<0.001) over the entire period 1989-2008. However survival increased substantially for OPSCC patients over time (5-year RS of 37.2% in 1989-1993 to 47.6% in 2004-2008, P<0.001). CONCLUSION: Although incidence of OPSCC did increase since 1989, especially in females, similar increases were seen for OCSCC (excl. oral tongue) and OTSCC. Our study does not appear to support that HPV is the main contributor to a rising incidence of OPSCC as the effects of changes in smoking and alcohol use cannot be discounted.
Authors: Fabrício Dos Santos Menezes; Maria do Rosário Dias de Oliveira Latorre; Gleice Margarete de Souza Conceição; Maria Paula Curado; José Leopoldo Ferreira Antunes; Tatiana Natasha Toporcov Journal: PLoS One Date: 2020-05-14 Impact factor: 3.240
Authors: Paolo Boscolo-Rizzo; Manuel Zorzi; Annarosa Del Mistro; Maria Cristina Da Mosto; Giancarlo Tirelli; Carlotta Buzzoni; Massimo Rugge; Jerry Polesel; Stefano Guzzinati Journal: PLoS One Date: 2018-02-07 Impact factor: 3.240
Authors: Lorena Baboci; Dana Holzinger; Paolo Boscolo-Rizzo; Giancarlo Tirelli; Roberto Spinato; Valentina Lupato; Roberto Fuson; Markus Schmitt; Angelika Michel; Gordana Halec; Maria Cristina Da Mosto; Michael Pawlita; Annarosa Del Mistro Journal: Papillomavirus Res Date: 2016-07-16
Authors: Andrew G Schache; Ned G Powell; Kate S Cuschieri; Max Robinson; Sam Leary; Hisham Mehanna; Davy Rapozo; Anna Long; Heather Cubie; Elizabeth Junor; Hannah Monaghan; Kevin J Harrington; Christopher M Nutting; Ulrike Schick; Andy S Lau; Navdeep Upile; Jon Sheard; Kath Brougham; Catharine M L West; Ken Oguejiofor; Steve Thomas; Andy R Ness; Miranda Pring; Gareth J Thomas; Emma V King; Dennis J McCance; Jacqueline A James; Michael Moran; Phil Sloan; Richard J Shaw; Mererid Evans; Terry M Jones Journal: Cancer Res Date: 2016-08-28 Impact factor: 13.312