Literature DB >> 26216302

Microsomal epoxide hydrolase 1 (EPHX1): Gene, structure, function, and role in human disease.

Radka Václavíková1, David J Hughes2, Pavel Souček3.   

Abstract

Microsomal epoxide hydrolase (EPHX1) is an evolutionarily highly conserved biotransformation enzyme for converting epoxides to diols. Notably, the enzyme is able to either detoxify or bioactivate a wide range of substrates. Mutations and polymorphic variants in the EPHX1 gene have been associated with susceptibility to several human diseases including cancer. This review summarizes the key knowledge concerning EPHX1 gene and protein structure, expression pattern and regulation, and substrate specificity. The relevance of EPHX1 for human pathology is especially discussed.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Disease; EPHX1; Function; Gene; Genotype; Structure

Mesh：

Substances：

Year:  2015        PMID： 26216302      PMCID： PMC4544754          DOI： 10.1016/j.gene.2015.07.071

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  130 in total

1.  Association between genetic polymorphisms and biomarkers in styrene-exposed workers.

Authors:  P Vodicka; P Soucek; A D Tates; M Dusinska; J Sarmanova; M Zamecnikova; L Vodickova; M Koskinen; F A de Zwart; A T Natarajan; K Hemminki
Journal:  Mutat Res       Date:  2001-10-01       Impact factor: 2.433

2.  Monoclonal antibodies reveal multiple forms of expression of human microsomal epoxide hydrolase.

Authors:  Hongying Duan; Akira Takagi; Hidekazu Kayano; Isamu Koyama; Christophe Morisseau; Bruce D Hammock; Toshitaka Akatsuka
Journal:  Toxicol Appl Pharmacol       Date:  2012-01-28       Impact factor: 4.219

3.  Membrane topology of epoxide hydrolase.

Authors:  J A Craft; S Baird; M Lamont; B Burchell
Journal:  Biochim Biophys Acta       Date:  1990-08-28

4.  Species differences in activating and inactivating enzymes related to the control of mutagenic metabolites.

Authors:  F Oesch; D Raphael; H Schwind; H R Glatt
Journal:  Arch Toxicol       Date:  1977-12-30       Impact factor: 5.153

5.  Gene evolution of epoxide hydrolases and recommended nomenclature.

Authors:  J K Beetham; D Grant; M Arand; J Garbarino; T Kiyosue; F Pinot; F Oesch; W R Belknap; K Shinozaki; B D Hammock
Journal:  DNA Cell Biol       Date:  1995-01       Impact factor: 3.311

6.  Purification of human liver microsomal epoxide hydrase. Differences in the properties of the human and rat enzymes.

Authors:  A Y Lu; P E Thomas; D Ryan; D M Jerina; W Levin
Journal:  J Biol Chem       Date:  1979-07-10       Impact factor: 5.157

7.  Functional analysis of human microsomal epoxide hydrolase genetic variants.

Authors:  Vinayak P Hosagrahara; Allan E Rettie; Christopher Hassett; Curtis J Omiecinski
Journal:  Chem Biol Interact       Date:  2004-11-20       Impact factor: 5.192

8.  Autoantibody response to microsomal epoxide hydrolase in hepatitis C and A.

Authors:  Toshitaka Akatsuka; Nobuharu Kobayashi; Takashi Ishikawa; Takafumi Saito; Michiko Shindo; Masayoshi Yamauchi; Kazutaka Kurokohchi; Hitoshi Miyazawa; Hongying Duan; Toshiyuki Matsunaga; Tsugikazu Komoda; Christophe Morisseau; Bruce D Hammock
Journal:  J Autoimmun       Date:  2007-02-12       Impact factor: 7.094

9.  Effect of epoxide hydrolase and glutathione S-tranferase genotypes on the induction of micronuclei and DNA damage by styrene-7,8-oxide in vitro.

Authors:  Blanca Laffon; Beatriz Pérez-Cadahía; Eduardo Pásaro; Josefina Méndez
Journal:  Mutat Res       Date:  2003-04-20       Impact factor: 2.433

10.  The expression of human microsomal epoxide hydrolase is predominantly driven by a genetically polymorphic far upstream promoter.

Authors:  Xi Yang; Shun-Hsin Liang; Denise M Weyant; Philip Lazarus; Carla J Gallagher; Curtis J Omiecinski
Journal:  J Pharmacol Exp Ther       Date:  2009-04-13       Impact factor: 4.030
View more
  25 in total

1.  Chiral lipidomics of monoepoxy and monohydroxy metabolites derived from long-chain polyunsaturated fatty acids.

Authors:  Maximilian Blum; Inci Dogan; Mirjam Karber; Michael Rothe; Wolf-Hagen Schunck
Journal:  J Lipid Res       Date:  2018-11-08       Impact factor: 5.922

2.  In Vitro Metabolism of Oprozomib, an Oral Proteasome Inhibitor: Role of Epoxide Hydrolases and Cytochrome P450s.

Authors:  Zhican Wang; Ying Fang; Juli Teague; Hansen Wong; Christophe Morisseau; Bruce D Hammock; Dan A Rock; Zhengping Wang
Journal:  Drug Metab Dispos       Date:  2017-04-20       Impact factor: 3.922

3.  Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia.

Authors:  Matthew L Edin; Behin Gholipour Hamedani; Artiom Gruzdev; Joan P Graves; Fred B Lih; Samuel J Arbes; Rohanit Singh; Anette C Orjuela Leon; J Alyce Bradbury; Laura M DeGraff; Samantha L Hoopes; Michael Arand; Darryl C Zeldin
Journal:  J Biol Chem       Date:  2018-01-03       Impact factor: 5.157

4.  Triphenyl phosphate is a selective PPARγ modulator that does not induce brite adipogenesis in vitro and in vivo.

Authors:  Stephanie Kim; Nabil Rabhi; Benjamin C Blum; Ryan Hekman; Kieran Wynne; Andrew Emili; Stephen Farmer; Jennifer J Schlezinger
Journal:  Arch Toxicol       Date:  2020-07-18       Impact factor: 5.153

5.  sEH promotes macrophage phagocytosis and lung clearance of Streptococcus pneumoniae.

Authors:  Hong Li; J Alyce Bradbury; Matthew L Edin; Joan P Graves; Artiom Gruzdev; Jennifer Cheng; Samantha L Hoopes; Laura M DeGraff; Michael B Fessler; Stavros Garantziotis; Shepherd H Schurman; Darryl C Zeldin
Journal:  J Clin Invest       Date:  2021-11-15       Impact factor: 14.808

6.  A single meal has the potential to alter brain oxylipin content.

Authors:  J E Norman; H H Aung; Y Otoki; Z Zhang; A Y Taha; J C Rutledge
Journal:  Prostaglandins Leukot Essent Fatty Acids       Date:  2020-01-30       Impact factor: 4.006

7.  Development of potent inhibitors of the human microsomal epoxide hydrolase.

Authors:  Bogdan Barnych; Nalin Singh; Sophie Negrel; Yue Zhang; Damien Magis; Capucine Roux; Xiude Hua; Zhewen Ding; Christophe Morisseau; Dean J Tantillo; Justin B Siegel; Bruce D Hammock
Journal:  Eur J Med Chem       Date:  2020-03-13       Impact factor: 6.514

Review 8.  Epoxy Fatty Acids Are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation.

Authors:  Cindy McReynolds; Christophe Morisseau; Karen Wagner; Bruce Hammock
Journal:  Adv Exp Med Biol       Date:  2020       Impact factor: 2.622

Review 9.  Prospective for cytochrome P450 epoxygenase cardiovascular and renal therapeutics.

Authors:  John D Imig
Journal:  Pharmacol Ther       Date:  2018-06-30       Impact factor: 12.310

10.  EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence.

Authors:  Jeremie Gautheron; Christophe Morisseau; Wendy K Chung; Jamila Zammouri; Martine Auclair; Genevieve Baujat; Emilie Capel; Celia Moulin; Yuxin Wang; Jun Yang; Bruce D Hammock; Barbara Cerame; Franck Phan; Bruno Fève; Corinne Vigouroux; Fabrizio Andreelli; Isabelle Jeru
Journal:  Elife       Date:  2021-08-03       Impact factor: 8.140
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.