Marienke A A M de Bruijn1, Nathalie E Synhaeve2, Mariëlle W A van Rijsbergen3, Frank-Erik de Leeuw4, Ruth E Mark5, Ben P W Jansen1, Paul L M de Kort1. 1. Department of Neurology, St. Elisabeth Hospital, Tilburg, The Netherlands. 2. Department of Neurology, St. Elisabeth Hospital, Tilburg, The Netherlands; Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands. Electronic address: n.synhaeve@elisabeth.nl. 3. Department of Neurology, St. Elisabeth Hospital, Tilburg, The Netherlands; Department of Cognitive Neuropsychology, Center of Research on Psychology in Somatic diseases, Tilburg University, Tilburg, The Netherlands. 4. Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands. 5. Department of Cognitive Neuropsychology, Center of Research on Psychology in Somatic diseases, Tilburg University, Tilburg, The Netherlands.
Abstract
BACKGROUND: Long-term prognosis in terms of quality of life (QoL) in young stroke patients is of importance because they usually have a long life expectancy and extensive daily life demands. We aimed at determining which medical and psychological factors influence the QoL in young stroke patients (<50 years), after long-term follow-up. METHODS: Young ischemic stroke patients admitted to the St. Elisabeth Hospital and the TweeSteden Hospital, Tilburg, the Netherlands, between 2000 and 2010 were included. One hundred seventy patients and 61 controls filled out the following questionnaires: (1) the Hospital Anxiety and Depression Scale, (2) the Fatigue Assessment Scale, and (3) the shortened World Health Organization Quality of Life scale. Using linear multiple regression analysis, we assessed the factors influencing QoL. RESULTS: QoL did not differ significantly between patients (median modified Rankin Scale score at follow-up, 0) and controls after a mean follow-up of 4.5 (standard deviation, 2.8) years. The presence of excessive fatigue was associated with lower scores on all domains of the QoL (P ≤ .003), but not for general health domain (P = .010). Similarly, depression was associated with worse QoL on the physical (P = .004) and psychological (P = .001) domains and anxiety with lower scores on the psychological (P < .001) QoL domain. No relationship was found between stroke-specific factors and QoL. CONCLUSIONS: Fatigue and to a lesser extent depression and anxiety affect the QoL in young adults after ischemic stroke of mild severity. Therefore, young stroke patients should be informed about, screened, and, if possible, treated for fatigue, depression, and anxiety.
BACKGROUND: Long-term prognosis in terms of quality of life (QoL) in young strokepatients is of importance because they usually have a long life expectancy and extensive daily life demands. We aimed at determining which medical and psychological factors influence the QoL in young strokepatients (<50 years), after long-term follow-up. METHODS: Young ischemic strokepatients admitted to the St. Elisabeth Hospital and the TweeSteden Hospital, Tilburg, the Netherlands, between 2000 and 2010 were included. One hundred seventy patients and 61 controls filled out the following questionnaires: (1) the Hospital Anxiety and Depression Scale, (2) the Fatigue Assessment Scale, and (3) the shortened World Health Organization Quality of Life scale. Using linear multiple regression analysis, we assessed the factors influencing QoL. RESULTS: QoL did not differ significantly between patients (median modified Rankin Scale score at follow-up, 0) and controls after a mean follow-up of 4.5 (standard deviation, 2.8) years. The presence of excessive fatigue was associated with lower scores on all domains of the QoL (P ≤ .003), but not for general health domain (P = .010). Similarly, depression was associated with worse QoL on the physical (P = .004) and psychological (P = .001) domains and anxiety with lower scores on the psychological (P < .001) QoL domain. No relationship was found between stroke-specific factors and QoL. CONCLUSIONS:Fatigue and to a lesser extent depression and anxiety affect the QoL in young adults after ischemic stroke of mild severity. Therefore, young strokepatients should be informed about, screened, and, if possible, treated for fatigue, depression, and anxiety.
Authors: Daniela Pinter; Simon Fandler-Höfler; Viktoria Fruhwirth; Lisa Berger; Gerhard Bachmaier; Susanna Horner; Sebastian Eppinger; Markus Kneihsl; Christian Enzinger; Thomas Gattringer Journal: Front Neurol Date: 2022-04-25 Impact factor: 4.086
Authors: Lukas Mayer-Suess; Moritz Geiger; Benjamin Dejakum; Christian Boehme; Lena M Domig; Silvia Komarek; Thomas Toell; Stefan Kiechl; Michael Knoflach Journal: Sci Rep Date: 2022-01-12 Impact factor: 4.996