| Literature DB >> 26214279 |
Yasushi Yoshida1, Makoto Sako, Kenta Kishi, Hiroaki Sasai, Susumi Hatakeyama, Shinobu Takizawa.
Abstract
A highly enantioselective aza-Morita-Baylis-Hillman (aza-MBH) reaction of isatin-derived ketimines with acrolein was established using β-isocupreidine (β-ICD) or α-isocupreine (α-ICPN) as a chiral acid-base organocatalyst. The present protocol readily furnished (S) or (R)-aza-MBH adducts with a chiral tetrasubstituted carbon stereogenic center in up to 98% ee.Entities:
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Year: 2015 PMID： 26214279 DOI： 10.1039/c5ob00874c
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876