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Literature DB >> 26212409

Thiyl radicals and induction of protein degradation.

Abstract

Thiyl radicals are important intermediates in the redox biology and chemistry of thiols. These radicals can react via hydrogen transfer with various C-H bonds in peptides and proteins, leading to the generation of carbon-centered radicals, and, potentially, to irreversible protein damage. This review summarizes quantitative information on reaction kinetics and product formation, and discusses the significance of these reactions for protein degradation induced by thiyl radical formation.

Entities: Chemical Disease Gene Species

Keywords: D-amino acids; Thiyl radicals; carbon-centered radicals; glutathione; hydrogen atom transfer

Mesh：

Substances：

Year: 2015 PMID： 26212409 PMCID： PMC5118943 DOI： 10.3109/10715762.2015.1077385

Source DB: PubMed Journal: Free Radic Res ISSN： 1029-2470

74 in total

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Journal: Free Radic Biol Med Date: 2014-09-30 Impact factor: 7.376

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Authors: Olivier Mozziconacci; Todd D Williams; Christian Schöneich
Journal: Chem Res Toxicol Date: 2012-07-03 Impact factor: 3.739

6. Protein thiyl radical mediates S-glutathionylation of complex I.

Authors: Patrick T Kang; Liwen Zhang; Chwen-Lih Chen; Jingfeng Chen; Kari B Green; Yeong-Renn Chen
Journal: Free Radic Biol Med Date: 2012-05-24 Impact factor: 7.376

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Journal: Int J Radiat Biol Relat Stud Phys Chem Med Date: 1987-01

10. Hydrogen exchange equilibria in glutathione radicals: rate constants.

Authors: Dustin Hofstetter; Thomas Nauser; Willem H Koppenol
Journal: Chem Res Toxicol Date: 2010-09-30 Impact factor: 3.739

13 in total

Review 1. Detection, identification, and quantification of oxidative protein modifications.

Authors: Clare L Hawkins; Michael J Davies
Journal: J Biol Chem Date: 2019-10-31 Impact factor: 5.157

2. Synchrotron X-radiolysis of l-cysteine at the sulfur K-edge: Sulfurous products, experimental surprises, and dioxygen as an oxidoreductant.

Authors: Patrick Frank; Ritimukta Sarangi; Britt Hedman; Keith O Hodgson
Journal: J Chem Phys Date: 2019-03-14 Impact factor: 3.488

Review 3. Protein cysteine oxidation in redox signaling: Caveats on sulfenic acid detection and quantification.

Authors: Henry Jay Forman; Michael J Davies; Anna C Krämer; Giovanni Miotto; Mattia Zaccarin; Hongqiao Zhang; Fulvio Ursini
Journal: Arch Biochem Biophys Date: 2016-09-28 Impact factor: 4.013

4. Identification of D-Amino Acids in Light Exposed mAb Formulations.

Authors: Rupesh Bommana; Natalia Subelzu; Olivier Mozziconacci; Alavattam Sreedhara; Christian Schöneich
Journal: Pharm Res Date: 2018-10-17 Impact factor: 4.200

5. α-((4-Cyanobenzoyl)oxy)-ω-methyl poly(ethylene glycol): a new stabilizer for silver nanoparticles.

Authors: Jana Lutze; Miguel A Bañares; Marcos Pita; Andrea Haase; Andreas Luch; Andreas Taubert
Journal: Beilstein J Nanotechnol Date: 2017-03-15 Impact factor: 3.649

6. Improving catalytic activity of the Baeyer-Villiger monooxygenase-based Escherichia coli biocatalysts for the overproduction of (Z)-11-(heptanoyloxy)undec-9-enoic acid from ricinoleic acid.

Authors: Ji-Min Woo; Eun-Yeong Jeon; Eun-Ji Seo; Joo-Hyun Seo; Dong-Yup Lee; Young Joo Yeon; Jin-Byung Park
Journal: Sci Rep Date: 2018-07-06 Impact factor: 4.379

Review 7. Plant Peroxisomes: A Factory of Reactive Species.

Authors: Francisco J Corpas; Salvador González-Gordo; José M Palma
Journal: Front Plant Sci Date: 2020-07-03 Impact factor: 5.753

Review 8. Oxidative Crosslinking of Peptides and Proteins: Mechanisms of Formation, Detection, Characterization and Quantification.

Authors: Eduardo Fuentes-Lemus; Per Hägglund; Camilo López-Alarcón; Michael J Davies
Journal: Molecules Date: 2021-12-21 Impact factor: 4.411

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Authors: Michael J Davies
Journal: Biochem J Date: 2016-04-01 Impact factor: 3.857

10. Reactivity of disulfide bonds is markedly affected by structure and environment: implications for protein modification and stability.

Authors: Maryam Karimi; Marta T Ignasiak; Bun Chan; Anna K Croft; Leo Radom; Carl H Schiesser; David I Pattison; Michael J Davies
Journal: Sci Rep Date: 2016-12-12 Impact factor: 4.379