Literature DB >> 26212118

The role of the bile acid chenodeoxycholic acid in the targeted oral delivery of the anti-diabetic drug gliclazide, and its applications in type 1 diabetes.

Sangeetha Mathavan1, Nigel Chen-Tan2, Frank Arfuso3, Hani Al-Salami1.   

Abstract

Gliclazide (G) is used to treat type 2 diabetes (T2D), and also has anti-platelet, anti-radical, and anti-inflammatory effects. G has poor water solubility and high inter-individual variations in absorption, limiting its application in type 1 diabetes (T1D). The bile acid, chenodeoxycholic acid (CDCA), has permeation-enhancing effects. Sodium alginate (SA) was used to microencapsulate G and CDCA to produce control (G-SA) and test (G-CDCA-SA) microcapsules. Both microcapsules showed uniform structure, morphology, and good stability profiles. CDCA reduced G-release at pH 7.8, while G-release was negligible at lower pH values in both microcapsules. CDCA incorporation resulted in less swelling and stronger microcapsules, suggesting improved stability.

Entities:  

Keywords:  artificial cell microencapsulation; bile acids; chenodeoxycholic acid; diabetes; gliclazide

Mesh：

Substances：

Year:  2015        PMID： 26212118     DOI： 10.3109/21691401.2015.1058807

Source DB:  PubMed          Journal:  Artif Cells Nanomed Biotechnol        ISSN： 2169-1401            Impact factor:   5.678


  10 in total

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Authors:  G Kaur; M Arora; M N V Ravi Kumar
Journal:  J Pharmacol Exp Ther       Date:  2019-04-22       Impact factor: 4.030

2.  High-Loading Dose of Microencapsulated Gliclazide Formulation Exerted a Hypoglycaemic Effect on Type 1 Diabetic Rats and Incorporation of a Primary Deconjugated Bile Acid, Diminished the Hypoglycaemic Antidiabetic Effect.

Authors:  Svetlana Golocorbin-Kon; Jelena Calasan; Boris Milijasevic; Sasa Vukmirovic; Mladena Lalic-Popovic; Momir Mikov; Hani Al-Salami
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2017-12       Impact factor: 2.441

3.  Metabolic and immunomodulatory control of type 1 diabetes via orally delivered bile-acid-polymer nanocarriers of insulin or rapamycin.

Authors:  Jung Seok Lee; Patrick Han; Rabib Chaudhury; Shihan Khan; Sean Bickerton; Michael D McHugh; Hyun Bong Park; Alyssa L Siefert; Gerald Rea; José M Carballido; David A Horwitz; Jason Criscione; Karlo Perica; Robert Samstein; Ragy Ragheb; Dongin Kim; Tarek M Fahmy
Journal:  Nat Biomed Eng       Date:  2021-10-06       Impact factor: 25.671

4.  Micro-Nano formulation of bile-gut delivery: rheological, stability and cell survival, basal and maximum respiration studies.

Authors:  Susbin Raj Wagle; Daniel Walker; Bozica Kovacevic; Ahmed Gedawy; Momir Mikov; Svetlana Golocorbin-Kon; Armin Mooranian; Hani Al-Salami
Journal:  Sci Rep       Date:  2020-05-07       Impact factor: 4.379

5.  Pharmacological Dose-Effect Profiles of Various Concentrations of Humanised Primary Bile Acid in Encapsulated Cells.

Authors:  Armin Mooranian; Melissa Jones; Daniel Walker; Corina Mihaela Ionescu; Susbin Raj Wagle; Bozica Kovacevic; Jacqueline Chester; Thomas Foster; Edan Johnston; Jafri Kuthubutheen; Daniel Brown; Marcus D Atlas; Momir Mikov; Hani Al-Salami
Journal:  Nanomaterials (Basel)       Date:  2022-02-15       Impact factor: 5.076

6.  Influence of Biotechnological Processes, Speed of Formulation Flow and Cellular Concurrent Stream-Integration on Insulin Production from β-cells as a Result of Co-Encapsulation with a Highly Lipophilic Bile Acid.

Authors:  Armin Mooranian; Rebecca Negrulj; Ryu Takechi; Emma Jamieson; Grant Morahan; Hani Al-Salami
Journal:  Cell Mol Bioeng       Date:  2017-10-03       Impact factor: 2.321

7.  A second-generation micro/nano capsules of an endogenous primary un-metabolised bile acid, stabilized by Eudragit-alginate complex with antioxidant compounds.

Authors:  Armin Mooranian; Nassim Zamani; Momir Mikov; Svetlana Goločorbin-Kon; Goran Stojanovic; Frank Arfuso; Bozica Kovacevic; Hani Al-Salami
Journal:  Saudi Pharm J       Date:  2019-12-07       Impact factor: 4.330

8.  Taurine Grafted Micro-Implants Improved Functions without Direct Dependency between Interleukin-6 and the Bile Acid Lithocholic Acid in Plasma.

Authors:  Armin Mooranian; Corina Mihaela Ionescu; Susbin Raj Wagle; Bozica Kovacevic; Daniel Walker; Melissa Jones; Jacqueline Chester; Thomas Foster; Edan Johnston; Sanja Kojic; Goran Stojanovic; Momir Mikov; Hani Al-Salami
Journal:  Biomedicines       Date:  2022-01-06

9.  Single-Cellular Biological Effects of Cholesterol-Catabolic Bile Acid-Based Nano/Micro Capsules as Anti-Inflammatory Cell Protective Systems.

Authors:  Armin Mooranian; Corina Mihaela Ionescu; Daniel Walker; Melissa Jones; Susbin Raj Wagle; Bozica Kovacevic; Jacqueline Chester; Thomas Foster; Edan Johnston; Jafri Kuthubutheen; Daniel Brown; Marcus D Atlas; Momir Mikov; Hani Al-Salami
Journal:  Biomolecules       Date:  2022-01-04

10.  The Effects of Primary Unconjugated Bile Acids on Nanoencapsulated Pharmaceutical Formulation of Hydrophilic Drugs: Pharmacological Implications.

Authors:  Armin Mooranian; Thomas Foster; Corina M Ionescu; Louise Carey; Daniel Walker; Melissa Jones; Susbin Raj Wagle; Bozica Kovacevic; Jacqueline Chester; Edan Johnstone; Jafri Kuthubutheen; Daniel Brown; Marcus D Atlas; Momir Mikov; Hani Al-Salami
Journal:  Drug Des Devel Ther       Date:  2021-10-23       Impact factor: 4.162
  10 in total

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