OBJECTIVES: To examine bone mineral density (BMD) in the spines of patients with juvenile idiopathic arthritis (JIA), and to identify the main predictors of spine BMD. METHODS: 160 patients with JIA (82 female, 78 male; median age, 8.7±3.9 years (range, 2.2-18.2 years)) who fulfilled the International League of Associations for Rheumatology (ILAR) criteria were enrolled. All subjects underwent an initial dual energy x-ray absorptiometry (DXA) scan of the lumbar spine, while 114 and 87 patients underwent a second and third scan, respectively. The data were compared with those obtained for 114 sex- and age-matched healthy controls. RESULTS: The DXA scans revealed that the JIA patients had a significant spine BMD deficit compared with control subjects (p<0.001). Longitudinal comparison of patients revealed no significant short-term improvement in the spine BMD. Spine BMD correlated with the age (p<0.05), subtype (p<0.05), and disease activity (p<0.01), BMI (p=0.001), glucocorticoid (GC) exposure (p< 0.05), methotrexate (MTX) therapy (p<0.05), and non-steroidal anti-inflammatory agents (NSAIDs) (p<0.05), erythrocyte sedimentation rate (ESR) (p<0.01), and C-reactive protein (CRP) levels (p<0.01). CONCLUSIONS: Patients with JIA have low bone mass, especially those in the polyarticular group >7 years old with higher disease activity.
OBJECTIVES: To examine bone mineral density (BMD) in the spines of patients with juvenile idiopathic arthritis (JIA), and to identify the main predictors of spine BMD. METHODS: 160 patients with JIA (82 female, 78 male; median age, 8.7±3.9 years (range, 2.2-18.2 years)) who fulfilled the International League of Associations for Rheumatology (ILAR) criteria were enrolled. All subjects underwent an initial dual energy x-ray absorptiometry (DXA) scan of the lumbar spine, while 114 and 87 patients underwent a second and third scan, respectively. The data were compared with those obtained for 114 sex- and age-matched healthy controls. RESULTS: The DXA scans revealed that the JIA patients had a significant spine BMD deficit compared with control subjects (p<0.001). Longitudinal comparison of patients revealed no significant short-term improvement in the spine BMD. Spine BMD correlated with the age (p<0.05), subtype (p<0.05), and disease activity (p<0.01), BMI (p=0.001), glucocorticoid (GC) exposure (p< 0.05), methotrexate (MTX) therapy (p<0.05), and non-steroidal anti-inflammatory agents (NSAIDs) (p<0.05), erythrocyte sedimentation rate (ESR) (p<0.01), and C-reactive protein (CRP) levels (p<0.01). CONCLUSIONS:Patients with JIA have low bone mass, especially those in the polyarticular group >7 years old with higher disease activity.
Authors: P C E Hissink Muller; W G van Braak; D Schreurs; C M Nusman; S A Bergstra; R Hemke; D Schonenberg-Meinema; J M van den Berg; T W Kuijpers; Y Koopman-Keemink; M A J van Rossum; L W A van Suijlekom-Smit; D M C Brinkman; C F Allaart; R Ten Cate; M Maas Journal: Pediatr Rheumatol Online J Date: 2019-09-04 Impact factor: 3.054
Authors: Liane D Heale; Saunya Dover; Y Ingrid Goh; Victoria A Maksymiuk; Greg D Wells; Brian M Feldman Journal: Pediatr Rheumatol Online J Date: 2018-10-22 Impact factor: 3.054