C Onwuneme1,2,3, B Diya4, O Uduma4, R A McCarthy4, N Murphy5, M T Kilbane6, M J McKenna7,6, E J Molloy4,7,8,9,10,11. 1. Department of Neonatology, National Maternity Hospital, Dublin, Ireland. chike.onwuneme@gmail.com. 2. Department of Paediatrics, Children's University Hospital, Temple Street, Dublin, Ireland. chike.onwuneme@gmail.com. 3. Department of Medicine & Medical Sciences, University College Dublin, Dublin, Ireland. chike.onwuneme@gmail.com. 4. Department of Neonatology, National Maternity Hospital, Dublin, Ireland. 5. Department of Paediatrics, Children's University Hospital, Temple Street, Dublin, Ireland. 6. Department of Metabolism and Endocrinology, St Vincent's University Hospital, Dublin, Ireland. 7. Department of Medicine & Medical Sciences, University College Dublin, Dublin, Ireland. 8. Department of Paediatrics, Department of Paediatrics, Royal College of Surgeons of Ireland, Dublin, Ireland. 9. Department of Neonatology, Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland. 10. Department of Paediatrics, Trinity College Dublin, Dublin, Ireland. 11. Department of Paediatrics, Trinity Centre for Health Sciences, Adelaide and Meath Hospital Dublin incorporating The National Children's Hospital (AMNCH), Tallaght, Dublin 24, Ireland.
Abstract
INTRODUCTION: Although the role of vitamin D in the prevention of rickets has long been well established, controversies still exist on the ideal dose of vitamin D supplementation in infants. OBJECTIVE: We assessed serum 25-hydroxyvitamin D (25OHD) status simultaneously in maternal and cord samples and the response to vitamin D3 supplementation in neonates. METHODS: Serum 25OHD levels were evaluated from maternal, and umbilical cord samples from term normal pregnancies. Repeat 25OHD levels were assessed in neonates with 25OHD below 30 nmol/L following vitamin D3 200 IU daily after 6 weeks. RESULTS: Blood samples were taken including 57 cord samples and 16 follow-up neonatal samples. Maternal and cord serum 25OHD were 43 ± 21 and 29 ± 15 nmol/L, respectively. Infants with 25OHD < 30 nmol/L (19.8 ± 4.7 nmol/L) had a significant increase in serum 25OHD (63.3 ± 14.5 nmol/L) following vitamin D3 200 IU daily after 6 weeks. CONCLUSION: Healthy Irish infants born at term are at high risk of vitamin D deficiency, but vitamin D3 200 IU daily, rapidly corrects poor vitamin D status.
INTRODUCTION: Although the role of vitamin D in the prevention of rickets has long been well established, controversies still exist on the ideal dose of vitamin D supplementation in infants. OBJECTIVE: We assessed serum 25-hydroxyvitamin D (25OHD) status simultaneously in maternal and cord samples and the response to vitamin D3 supplementation in neonates. METHODS: Serum 25OHD levels were evaluated from maternal, and umbilical cord samples from term normal pregnancies. Repeat 25OHD levels were assessed in neonates with 25OHD below 30 nmol/L following vitamin D3 200 IU daily after 6 weeks. RESULTS: Blood samples were taken including 57 cord samples and 16 follow-up neonatal samples. Maternal and cord serum 25OHD were 43 ± 21 and 29 ± 15 nmol/L, respectively. Infants with 25OHD < 30 nmol/L (19.8 ± 4.7 nmol/L) had a significant increase in serum 25OHD (63.3 ± 14.5 nmol/L) following vitamin D3 200 IU daily after 6 weeks. CONCLUSION: Healthy Irish infants born at term are at high risk of vitamin D deficiency, but vitamin D3 200 IU daily, rapidly corrects poor vitamin D status.
Entities:
Keywords:
Neonates; Supplementation; Term infants; Vitamin D
Authors: Giuseppe Saggese; Francesco Vierucci; Flavia Prodam; Fabio Cardinale; Irene Cetin; Elena Chiappini; Gian Luigi De' Angelis; Maddalena Massari; Emanuele Miraglia Del Giudice; Michele Miraglia Del Giudice; Diego Peroni; Luigi Terracciano; Rino Agostiniani; Domenico Careddu; Daniele Giovanni Ghiglioni; Gianni Bona; Giuseppe Di Mauro; Giovanni Corsello Journal: Ital J Pediatr Date: 2018-05-08 Impact factor: 2.638