Iemke Sarrechia1, Marijke Miatton2, Katrien François3, Marc Gewillig4, Bart Meyns5, Guy Vingerhoets6, Daniël De Wolf7. 1. Department of Experimental Psychology, Ghent University, Henri Dunantlaan 2, 9000 Ghent, Belgium. Electronic address: iemke.sarrechia@gmail.com. 2. Department of Neurology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. 3. Congenital Cardiac Surgery, Department of Cardiac Surgery, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. 4. Pediatric and Congenital Cardiology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium. 5. Pediatric and Congenital Cardiothoracic Surgery, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium. 6. Department of Experimental Psychology, Ghent University, Henri Dunantlaan 2, 9000 Ghent, Belgium. 7. Department of Pediatrics-Pediatric Cardiology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium.
Abstract
BACKGROUND: Inconsistent results on neuropsychological outcome in patients treated for acyanotic congenital heart disease (aCHD) questioned the clinical relevance of possible neurobehavioral sequelae in this group. This study was designed to objectify the neuropsychological profile and evaluate associations with medical data. METHODS: Patients with a corrected atrial or ventricular septal defect, ASD-II or VSD, (n=46; mean age 9 years, 2 months) and a matched control group were submitted to an intelligence test (Wechsler Intelligence Scale for Children, third edition, Dutch version) and evaluated with a neuropsychological test battery (Developmental Neuropsychological Assessment, second edition, Dutch version). Hospitalization variables were retrieved to evaluate associations with cognitive outcome. Parents completed a behavioral checklist (Achenbach Child Behavior Checklist for Children aged 6-18). RESULTS: ASD-II patients showed lower scores in domains of visuospatial processing, language, attention, and social perception. VSD patients displayed subtle problems in attention and visuospatial information processing. Only few perioperative medical factors, but also socioeconomic variables were associated with cognitive outcomes. Parents of ASD-II patients reported more school problems when compared to controls. CONCLUSIONS: After treatment for aCHD, subtle cognitive difficulties can present in domains of visuospatial information processing, language, attention, and social perception. These shortcomings might hamper school performances, as is suggested by lower school competence ratings. Ongoing follow-up and cognitive screening is warranted to promote developmental progress, in which both parents and clinicians share responsibility.
BACKGROUND: Inconsistent results on neuropsychological outcome in patients treated for acyanotic congenital heart disease (aCHD) questioned the clinical relevance of possible neurobehavioral sequelae in this group. This study was designed to objectify the neuropsychological profile and evaluate associations with medical data. METHODS:Patients with a corrected atrial or ventricular septal defect, ASD-II or VSD, (n=46; mean age 9 years, 2 months) and a matched control group were submitted to an intelligence test (Wechsler Intelligence Scale for Children, third edition, Dutch version) and evaluated with a neuropsychological test battery (Developmental Neuropsychological Assessment, second edition, Dutch version). Hospitalization variables were retrieved to evaluate associations with cognitive outcome. Parents completed a behavioral checklist (Achenbach Child Behavior Checklist for Children aged 6-18). RESULTS:ASD-IIpatients showed lower scores in domains of visuospatial processing, language, attention, and social perception. VSDpatients displayed subtle problems in attention and visuospatial information processing. Only few perioperative medical factors, but also socioeconomic variables were associated with cognitive outcomes. Parents of ASD-IIpatients reported more school problems when compared to controls. CONCLUSIONS: After treatment for aCHD, subtle cognitive difficulties can present in domains of visuospatial information processing, language, attention, and social perception. These shortcomings might hamper school performances, as is suggested by lower school competence ratings. Ongoing follow-up and cognitive screening is warranted to promote developmental progress, in which both parents and clinicians share responsibility.
Authors: Benjamin Asschenfeldt; Lars Evald; Johan Heiberg; Camilla Salvig; Leif Østergaard; Rikke Beese Dalby; Simon Fristed Eskildsen; Vibeke Elisabeth Hjortdal Journal: J Am Heart Assoc Date: 2020-05-19 Impact factor: 5.501
Authors: Martina Brueckner; Mustafa K Khokha; Laura R Ment; Weizhen Ji; Dina Ferdman; Joshua Copel; Dustin Scheinost; Veronika Shabanova Journal: Sci Rep Date: 2020-04-27 Impact factor: 4.379
Authors: Melinda Barkhuizen; Raul Abella; J S Hans Vles; Luc J I Zimmermann; Diego Gazzolo; Antonio W D Gavilanes Journal: Pediatr Cardiol Date: 2020-12-29 Impact factor: 1.655