| Literature DB >> 26210037 |
Naimat Kalim Bari1, Mohammad Fazil2, Md Quamrul Hassan3, Md Rafi Haider4, Bharti Gaba2, Jasjeet K Narang5, Sanjula Baboota2, Javed Ali6.
Abstract
The present work discusses the preparation, characterization and in vivo evaluation of thiolated chitosan nanoparticles (TCS-NPs) of buspirone hydrochloride (BUH) for brain delivery through intranasal route. TCS NPs were prepared by ionic gelation method and characterized for various parameters. The NPs formed were having particle size of 226.7±2.52nm with PDI 0.483±0.031. Drug entrapment efficiency (EE) and loading capacity (LC) were found to be 81.13±2.8 and 49.67±5.5%. The cumulative percentage drug permeation through nasal mucosa was 76.21%. Bioadhesion study carried out on porcine mucin and showed a bioadhesion efficiency of 90.218±0.134%. Nose-to-brain delivery of placebo NPs was investigated by confocal laser scanning microscopy (CLSM) technique using rhodamine-123 as a marker. The brain concentration achieved after intranasal administration of TCS-NPs was 797.46±35.76ng/ml with tmax 120min which was significantly higher than achieved after intravenous administration on BUH solution 384.15±13.42ng/ml and tmax of 120min and intranasal administration of BUH solution 417.77±19.24ng/ml and tmax 60min.Entities:
Keywords: Buspirone hydrochloride (BUH); General anxiety disorder; Intra nasal; Nanoparticles; Nose to brain; Thiolated chitosan
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Year: 2015 PMID： 26210037 DOI： 10.1016/j.ijbiomac.2015.07.041
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953