Thomas M Snow1, Peter Ludman2, Winston Banya3, Mark DeBelder4, Philip M MacCarthy5, Simon W Davies1, Carlo Di Mario3, Neil E Moat6. 1. Cardiovascular Biomedical Research Unit Royal Brompton & Harefield NHS Foundation Trust, London, UK. 2. Queen Elizabeth Hospital, Birmingham, UK. 3. Cardiovascular Biomedical Research Unit Royal Brompton & Harefield NHS Foundation Trust, London, UK; Imperial College, London, UK. 4. The James Cook University Hospital, Middlesbrough, UK. 5. King's College Hospital, London, UK. 6. Cardiovascular Biomedical Research Unit Royal Brompton & Harefield NHS Foundation Trust, London, UK. Electronic address: n.moat@rbht.nhs.uk.
Abstract
BACKGROUND: The management and impact of concomitant coronary artery disease in patients referred for TAVI remains contentious. We describe the prevalence, clinical impact and management of coronary artery disease (CAD) in patients in the United Kingdom TAVI Registry. METHODS: All-inclusive study of patients undergoing TAVI in the United Kingdom (excluding Northern Ireland) from January 2007 to December 2011. Coronary artery disease at the time of TAVI was demonstrated on invasive angiography. RESULTS: 2588 consecutive patients were entered in the U.K. TAVI Registry. CAD was reported in 1171 pts with left main stem involvement in 12.4% of this cohort (n=145). Most patients were free of chest pain, but limited by dyspnoea (NYHA Class III & IV 81.9%). Angina was however more prevalent in those patients with CAD (p<0.0001). Hybrid PCI was uncommon, performed in only 14.7% of the CAD cohort (n=172). Survival at 30days, 1year, and 4years was 93.7%, 81.4% and 72.0% respectively. Adjusting for confounders in a multivariate model the presence and extent of CAD was not associated with early (30-days, p=0.36) or late (4years, p=0.10) survival. CONCLUSIONS: This contemporary study of coronary artery disease management in an "all-comers" patient population undergoing TAVI demonstrates that whilst often an indicator of significant underlying comorbidity coronary artery disease is not associated with decreased short or long-term survival. The majority of patients with aortic stenosis and concomitant CAD can be managed effectively by TAVI alone. However, the importance of the Heart Team in making decisions on individual patients must not be underestimated.
BACKGROUND: The management and impact of concomitant coronary artery disease in patients referred for TAVI remains contentious. We describe the prevalence, clinical impact and management of coronary artery disease (CAD) in patients in the United Kingdom TAVI Registry. METHODS: All-inclusive study of patients undergoing TAVI in the United Kingdom (excluding Northern Ireland) from January 2007 to December 2011. Coronary artery disease at the time of TAVI was demonstrated on invasive angiography. RESULTS: 2588 consecutive patients were entered in the U.K. TAVI Registry. CAD was reported in 1171 pts with left main stem involvement in 12.4% of this cohort (n=145). Most patients were free of chest pain, but limited by dyspnoea (NYHA Class III & IV 81.9%). Angina was however more prevalent in those patients with CAD (p<0.0001). Hybrid PCI was uncommon, performed in only 14.7% of the CAD cohort (n=172). Survival at 30days, 1year, and 4years was 93.7%, 81.4% and 72.0% respectively. Adjusting for confounders in a multivariate model the presence and extent of CAD was not associated with early (30-days, p=0.36) or late (4years, p=0.10) survival. CONCLUSIONS: This contemporary study of coronary artery disease management in an "all-comers" patient population undergoing TAVI demonstrates that whilst often an indicator of significant underlying comorbidity coronary artery disease is not associated with decreased short or long-term survival. The majority of patients with aortic stenosis and concomitant CAD can be managed effectively by TAVI alone. However, the importance of the Heart Team in making decisions on individual patients must not be underestimated.
Authors: Anna Kostopoulou; Panagiotis Karyofillis; Efthimios Livanis; George Karavolias; George Theodorakis; John Paraskevaides; Vassilis Voudris Journal: Curr Treat Options Cardiovasc Med Date: 2016-02
Authors: Rafail A Kotronias; Chun Shing Kwok; Sudhakar George; Davide Capodanno; Peter F Ludman; Jonathan N Townend; Sagar N Doshi; Saib S Khogali; Philippe Généreux; Howard C Herrmann; Mamas A Mamas; Rodrigo Bagur Journal: J Am Heart Assoc Date: 2017-06-27 Impact factor: 5.501
Authors: Marko P O Virtanen; Markku Eskola; Maina P Jalava; Annastiina Husso; Teemu Laakso; Matti Niemelä; Tuomas Ahvenvaara; Tuomas Tauriainen; Pasi Maaranen; Eeva-Maija Kinnunen; Sebastian Dahlbacka; Jussi Jaakkola; Tuija Vasankari; Juhani Airaksinen; Vesa Anttila; Stefano Rosato; Paola D'Errigo; Mikko Savontaus; Tatu Juvonen; Mika Laine; Timo Mäkikallio; Antti Valtola; Peter Raivio; Fausto Biancari Journal: JAMA Netw Open Date: 2019-06-05