| Literature DB >> 26209560 |
Kairong Wang1, Wen Dang1, Junqiu Xie1, Ranran Zhu1, Mengyang Sun1, Fengjing Jia1, Yanyan Zhao1, Xiaoping An1, Shuai Qiu1, Xiaoyuan Li1, Zelin Ma1, Wenjin Yan2, Rui Wang3.
Abstract
Candidiasis is often observed in immunocompromised patients and is the 4th most common cause of bloodstream infections. However, antifungals are limited, so novel antifungal agents are urgently needed. Antimicrobial peptides (AMPs) are considered as potential alternatives of conventional antibiotics. In the present study, antimicrobial peptide protonectin was chemically synthesized and its antifungal activity and mode of action were studied. Our results showed that protonectin has potent antifungal activity and fungicidal activity against the tested fungi cells. Its action mode involved the disruption of the membrane integrity and the inducing of the production of cellular ROS. Furthermore, protonectin could inhibit the formation of biofilm and kill the adherent fungi cells. In conclusion, with the increase of fungal infection, protonectin may offer a new strategy and be considered as a potential therapeutic agent against fungal disease.Entities:
Keywords: Antifungal; Biofilm formation; Protonectin; ROS production
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Year: 2015 PMID： 26209560 DOI： 10.1016/j.bbamem.2015.07.008
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002