Aron S Buchman1, Robert S Wilson2, Sue E Leurgans3, David A Bennett4, Lisa L Barnes5. 1. Rush Alzheimer's Disease Center, Rush University Medical Center, United States; Department of Neurological Sciences, Rush University Medical Center, United States. Electronic address: Aron_S_Buchman@rush.edu. 2. Rush Alzheimer's Disease Center, Rush University Medical Center, United States; Department of Behavioral Sciences, Rush University Medical Center, United States. Electronic address: rwilson@rush.edu. 3. Rush Alzheimer's Disease Center, Rush University Medical Center, United States; Department of Neurological Sciences, Rush University Medical Center, United States. Electronic address: Sue_E_Leurgans@rush.edu. 4. Rush Alzheimer's Disease Center, Rush University Medical Center, United States; Department of Neurological Sciences, Rush University Medical Center, United States. Electronic address: David_A_Bennett@rush.edu. 5. Rush Alzheimer's Disease Center, Rush University Medical Center, United States; Department of Neurological Sciences, Rush University Medical Center, United States; Department of Behavioral Sciences, Rush University Medical Center, United States. Electronic address: Lisa_L_Barnes@rush.edu.
Abstract
OBJECTIVE: We tested whether declining motor function accelerates with age in older African-Americans. METHODS: Eleven motor performances were assessed annually in 513 older African-Americans. RESULTS: During follow-up of 5 years, linear mixed-effect models showed that motor function declined by about 0.03 units/year (Estimate, -0.026, p<0.001); about 4% more rapidly for each additional year of age at baseline. A proportional hazard model showed that both baseline motor function level and its rate of change were independent predictors of death and incident disability (all p's<0.001). These models showed that the additional annual amount of motor decline in 85 year old persons at baseline versus 65 year old persons was associated with a 1.5-fold higher rate of death and a 3-fold higher rate of developing Katz disability. CONCLUSIONS: The rate of declining motor function accelerates with increasing age and its rate of decline predicts adverse health outcomes in older African-Americans.
OBJECTIVE: We tested whether declining motor function accelerates with age in older African-Americans. METHODS: Eleven motor performances were assessed annually in 513 older African-Americans. RESULTS: During follow-up of 5 years, linear mixed-effect models showed that motor function declined by about 0.03 units/year (Estimate, -0.026, p<0.001); about 4% more rapidly for each additional year of age at baseline. A proportional hazard model showed that both baseline motor function level and its rate of change were independent predictors of death and incident disability (all p's<0.001). These models showed that the additional annual amount of motor decline in 85 year old persons at baseline versus 65 year old persons was associated with a 1.5-fold higher rate of death and a 3-fold higher rate of developing Katz disability. CONCLUSIONS: The rate of declining motor function accelerates with increasing age and its rate of decline predicts adverse health outcomes in older African-Americans.
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