| Literature DB >> 26208805 |
Luis García-García1,2, Ahmed Anis Shiha3, Pablo Bascuñana3, Javier de Cristóbal3, Rubén Fernández de la Rosa3, Mercedes Delgado3,4, Miguel A Pozo3,5.
Abstract
It has been reported that fluoxetine, a selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor, has neuroprotective properties in the lithium-pilocarpine model of status epilepticus (SE) in rats. The aim of the present study was to investigate the effect of 5-HT depletion by short-term administration of p-chlorophenylalanine (PCPA), a specific tryptophan hydroxylase inhibitor, on the brain hypometabolism and neurodegeneration induced in the acute phase of this SE model. Our results show that 5-HT depletion did modify neither the brain basal metabolic activity nor the lithium-pilocarpine-induced hypometabolism when evaluated 3 days after the insult. In addition, hippocampal neurodegeneration and astrogliosis triggered by lithium-pilocarpine were not exacerbated by PCPA treatment. These findings point out that in the early latent phase of epileptogenesis, non-5-HT-mediated actions may contribute, at least in some extent, to the neuroprotective effects of fluoxetine in this model of SE.Entities:
Keywords: Fluoro-Jade C; Lithium–pilocarpine; Serotonin; Status epilepticus; [18F]FDG PET; p-Chlorophenylalanine
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Year: 2015 PMID： 26208805 DOI： 10.1007/s10571-015-0240-4
Source DB: PubMed Journal: Cell Mol Neurobiol ISSN： 0272-4340 Impact factor: 5.046