Yi Wang1, Ye Tian2, Dong Wang3, Huijie Wei4, Zilong Zhao5, Rongcai Jiang6, Shuyuan Yue7, Jianning Zhang8. 1. Department of Neurosurgery, Tianjin Medical University General Hospital, China; Tianjin Neurological Institute, China; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education in China, China; Key Laboratory of Injuries, Variations and Regeneration of Nervous System in Tianjin, 154 Anshan Road, Tianjin 300052, China. Electronic address: sinuosiwo@sina.com. 2. Department of Neurosurgery, Tianjin Medical University General Hospital, China; Tianjin Neurological Institute, China; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education in China, China; Key Laboratory of Injuries, Variations and Regeneration of Nervous System in Tianjin, 154 Anshan Road, Tianjin 300052, China. Electronic address: yetian1986@gmail.com. 3. Department of Neurosurgery, Tianjin Medical University General Hospital, China; Tianjin Neurological Institute, China; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education in China, China; Key Laboratory of Injuries, Variations and Regeneration of Nervous System in Tianjin, 154 Anshan Road, Tianjin 300052, China. Electronic address: 54454241@qq.com. 4. Department of Neurosurgery, Tianjin Medical University General Hospital, China; Tianjin Neurological Institute, China; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education in China, China; Key Laboratory of Injuries, Variations and Regeneration of Nervous System in Tianjin, 154 Anshan Road, Tianjin 300052, China. Electronic address: huijiewei@126.com. 5. Department of Neurosurgery, Tianjin Medical University General Hospital, China; Tianjin Neurological Institute, China; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education in China, China; Key Laboratory of Injuries, Variations and Regeneration of Nervous System in Tianjin, 154 Anshan Road, Tianjin 300052, China. Electronic address: zilongzhaotianjin@hotmail.com. 6. Department of Neurosurgery, Tianjin Medical University General Hospital, China; Tianjin Neurological Institute, China; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education in China, China; Key Laboratory of Injuries, Variations and Regeneration of Nervous System in Tianjin, 154 Anshan Road, Tianjin 300052, China. Electronic address: jianghope@gmail.com. 7. Department of Neurosurgery, Tianjin Medical University General Hospital, China; Tianjin Neurological Institute, China; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education in China, China; Key Laboratory of Injuries, Variations and Regeneration of Nervous System in Tianjin, 154 Anshan Road, Tianjin 300052, China. Electronic address: shuyuanyue@sina.com. 8. Department of Neurosurgery, Tianjin Medical University General Hospital, China; Tianjin Neurological Institute, China; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education in China, China; Key Laboratory of Injuries, Variations and Regeneration of Nervous System in Tianjin, 154 Anshan Road, Tianjin 300052, China. Electronic address: jianningzhang@hotmail.com.
Abstract
BACKGROUND: The consequences of aneurysmal subarachnoid hemorrhage (aSAH) are lifelong and fatal. Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) play an important role in the regulation of vascular structure and function. Our study examined the association between angiopoietin levels and functional outcomes among aSAH patients. METHODS: We enrolled 37 aSAH patients and 39 controls (matched on age and sex) at the Department of Neurosurgery in Tianjin Medical University General Hospital. Serum Ang-1, Ang-2, and Tie-2 levels were collected at 8, 24, and 72 hours post-hemorrhage. After a 3-month follow-up period, patient outcomes were evaluated using the Glasgow Outcome Score (GOS). Logistic regression examined the association between angiopoietin levels and outcomes (good [GOS: 4-5] vs. poor [GOS: 1-3]). RESULTS: aSAH patients had higher levels of Ang-1 at 8 hours post-hemorrhage compared to controls. Among aSAH patients, Ang-1 levels at 8, 24, and 72 hours post-hemorrhage were higher among patients with a good outcome. Compared to patients with low Ang-1 levels, high Ang-1 levels at 72 hours post-hemorrhage were associated with a good outcome. CONCLUSIONS: High Ang-1 levels were associated with a good functional outcome after aSAH. Abnormal angiopoietin levels may disrupt the blood-brain barrier and contribute to functional outcomes in aSAH patients.
BACKGROUND: The consequences of aneurysmal subarachnoid hemorrhage (aSAH) are lifelong and fatal. Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) play an important role in the regulation of vascular structure and function. Our study examined the association between angiopoietin levels and functional outcomes among aSAH patients. METHODS: We enrolled 37 aSAH patients and 39 controls (matched on age and sex) at the Department of Neurosurgery in Tianjin Medical University General Hospital. Serum Ang-1, Ang-2, and Tie-2 levels were collected at 8, 24, and 72 hours post-hemorrhage. After a 3-month follow-up period, patient outcomes were evaluated using the Glasgow Outcome Score (GOS). Logistic regression examined the association between angiopoietin levels and outcomes (good [GOS: 4-5] vs. poor [GOS: 1-3]). RESULTS: aSAH patients had higher levels of Ang-1 at 8 hours post-hemorrhage compared to controls. Among aSAH patients, Ang-1 levels at 8, 24, and 72 hours post-hemorrhage were higher among patients with a good outcome. Compared to patients with low Ang-1 levels, high Ang-1 levels at 72 hours post-hemorrhage were associated with a good outcome. CONCLUSIONS: High Ang-1 levels were associated with a good functional outcome after aSAH. Abnormal angiopoietin levels may disrupt the blood-brain barrier and contribute to functional outcomes in aSAH patients.
Authors: Alan Leviton; Olaf Dammann; Elizabeth N Allred; Robert M Joseph; Raina N Fichorova; T Michael O'Shea; Karl C K Kuban Journal: Int J Dev Neurosci Date: 2018-02-02 Impact factor: 2.457
Authors: Dongjing Liu; Annie I Arockiaraj; John R Shaffer; Samuel M Poloyac; Paula R Sherwood; Sheila A Alexander; Elizabeth A Crago; Daniel E Weeks; Yvette P Conley Journal: Epigenetics Commun Date: 2021-12-20