Literature DB >> 26208572

Evidence for the presence of clofazimine and its distribution in the healthy mouse brain.

Sooraj Baijnath1, Suhashni Naiker, Adeola Shobo, Chivonne Moodley, John Adamson, Bongani Ngcobo, Linda A Bester, Sanil Singh, Hendrik G Kruger, Tricia Naicker, Thavendran Govender.   

Abstract

This is the first report of clofazimine (CFZ) penetration and distribution in normal mouse brain. Mice were administered 25 mg/kg CFZ or 100 mg/kg CFZ orally, daily for 2 weeks. Animals were sacrificed and blood and brain tissues were harvested. Liquid chromatography tandem mass spectrometry showed high concentrations of CFZ in homogenized brain, with 100 mg/kg dose having significantly higher concentration than 25 mg/kg. Matrix-assisted laser desorption/ionization spectrometric imaging of brain sections showed widespread tissue distribution of CFZ. Our results show dose dependent localization in brain.

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Year:  2015        PMID： 26208572     DOI： 10.1007/s10735-015-9634-3

Source DB:  PubMed          Journal:  J Mol Histol        ISSN： 1567-2379            Impact factor:   2.611


  14 in total

1.  Antituberculosis activity in the phenazine series; isomeric pigments obtained by oxidation of o-phenylenediamine derivatives.

Authors:  V C BARRY; M L CONALTY; E E GAFFNEY
Journal:  J Pharm Pharmacol       Date:  1956-12       Impact factor: 3.765

2.  Short, highly effective, and inexpensive standardized treatment of multidrug-resistant tuberculosis.

Authors:  Armand Van Deun; Aung Kya Jai Maug; Md Abdul Hamid Salim; Pankaj Kumar Das; Mihir Ranjan Sarker; Paul Daru; Hans L Rieder
Journal:  Am J Respir Crit Care Med       Date:  2010-05-04       Impact factor: 21.405

3.  Tissue distribution of pretomanid in rat brain via mass spectrometry imaging.

Authors:  Adeola Shobo; Dominika Bratkowska; Sooraj Baijnath; Suhashni Naiker; Anou M Somboro; Linda A Bester; Sanil D Singh; Tricia Naicker; Hendrik G Kruger; Thavendran Govender
Journal:  Xenobiotica       Date:  2015-07-24       Impact factor: 1.908

4.  Clofazimine shortens the duration of the first-line treatment regimen for experimental chemotherapy of tuberculosis.

Authors:  Sandeep Tyagi; Nicole C Ammerman; Si-Yang Li; John Adamson; Paul J Converse; Rosemary V Swanson; Deepak V Almeida; Jacques H Grosset
Journal:  Proc Natl Acad Sci U S A       Date:  2015-01-05       Impact factor: 11.205

5.  Visualization of Time-Dependent Distribution of Rifampicin in Rat Brain Using MALDI MSI and Quantitative LCMS/MS.

Authors:  Adeola Shobo; Dominika Bratkowska; Sooraj Baijnath; Suhashni Naiker; Linda A Bester; Sanil D Singh; Glenn Eamond Mitchell Maguire; Hendrik Gert Kruger; Thavendran Govender
Journal:  Assay Drug Dev Technol       Date:  2015-06-12       Impact factor: 1.738

6.  Clofazimine in the treatment of multidrug-resistant tuberculosis.

Authors:  H-B Xu; R-H Jiang; H-P Xiao
Journal:  Clin Microbiol Infect       Date:  2011-12-22       Impact factor: 8.067

Review 7.  Clofazimine: current status and future prospects.

Authors:  Moloko C Cholo; Helen C Steel; P B Fourie; Willem A Germishuizen; Ronald Anderson
Journal:  J Antimicrob Chemother       Date:  2011-10-20       Impact factor: 5.790

8.  Antituberculosis activity in the phenazine series. II. N3-substituted anilinoaposafranines (rimino-compounds) and some derivatives.

Authors:  V C BARRY; M L CONALTY
Journal:  Am Rev Tuberc       Date:  1958-07

Review 9.  Clinical pharmacokinetic considerations in the treatment of patients with leprosy.

Authors:  K Venkatesan
Journal:  Clin Pharmacokinet       Date:  1989-06       Impact factor: 6.447

10.  Tissue concentrations of clofazimine (B663) in man.

Authors:  R E Mansfield
Journal:  Am J Trop Med Hyg       Date:  1974-11       Impact factor: 2.345
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  6 in total

1.  Neuroprotective potential of Linezolid: a quantitative and distribution study via mass spectrometry.

Authors:  Sooraj Baijnath; Adeola Shobo; Linda A Bester; Sanil D Singh; Gert Kruger; Per I Arvidsson; Tricia Naicker; Thavendran Govender
Journal:  J Mol Histol       Date:  2016-06-21       Impact factor: 2.611

2.  Post heroin dose tissue distribution of 6-monoacetylmorphine (6-MAM) with MALDI imaging.

Authors:  Belin G Teklezgi; Annapurna Pamreddy; Sooraj Baijnath; Nirmala D Gopal; Tricia Naicker; Hendrik G Kruger; Thavendran Govender
Journal:  J Mol Histol       Date:  2017-05-26       Impact factor: 2.611

3.  Determining protein biomarkers for DLBCL using FFPE tissues from HIV negative and HIV positive patients.

Authors:  Pumza Magangane; Raveendra Sookhayi; Dhirendra Govender; Richard Naidoo
Journal:  J Mol Histol       Date:  2016-10-01       Impact factor: 2.611

4.  Small molecule distribution in rat lung: a comparison of various cryoprotectants as inflation media and their applicability to MSI.

Authors:  Sooraj Baijnath; Adeola Shobo; Linda A Bester; Sanil D Singh; Gert Kruger; Tricia Naicker; Thavendran Govender
Journal:  J Mol Histol       Date:  2016-01-13       Impact factor: 2.611

5.  Bedaquiline has potential for targeting tuberculosis reservoirs in the central nervous system.

Authors:  Annapurna Pamreddy; Sooraj Baijnath; Tricia Naicker; Sphamandla Ntshangase; Sipho Mdanda; Hlengekile Lubanyana; Hendrik G Kruger; Thavendran Govender
Journal:  RSC Adv       Date:  2018-03-28       Impact factor: 4.036

6.  Clinical outcomes among patients with tuberculous meningitis receiving intensified treatment regimens.

Authors:  A G C Smith; M Gujabidze; T Avaliani; H M Blumberg; J M Collins; S Sabanadze; T Bakuradze; Z Avaliani; R R Kempker; M Kipiani
Journal:  Int J Tuberc Lung Dis       Date:  2021-08-01       Impact factor: 3.427
  6 in total

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