Folate-polydiacetylene-liposome for tumor targeted drug delivery and fluorescent tracing.

A novel folate-polydiacetylene-liposome (FP-PL) with both targeted drug delivery and fluorescence tracing was prepared by thin film rehydration method. The simulated drug delivery was performed in Bcap-37 breast cancer cells and Hs578Bst normal cells in vitro. The internalization and distribution of FP-PLs in the cells were presented by fluorescence cell imaging. The results show that the FP-PLs possess low cytotoxicity, good biocompatibility and better targeting efficiency in comparison to polydiacetylene-liposomes (P-PLs).