Genomic imprinting: normal complementation of murine chromosome 16.

Parental imprinting effects for chromosome 16 were investigated using disomic animals which were obtained by mating (Rb32Lub x Rb2H) F1 mice. Two allelic forms of the enzyme CuZn-superoxide dismutase, Sod-1a and Sod-1c, were used to identify maternally or paternally disomic animals. Both types of disomic animals were found with the expected frequencies and did not visibly differ from one another or from non-disomic animals. These results indicate that the genomic imprinting mechanism either does not act on chromosome 16, or, if it does, does not do so in a manner which affects normal development.