Literature DB >> 26207329

Challenges, Progresses, and Promises for Developing Future NADPH Oxidase Therapeutics.

Karen Bedard1, Scott Whitehouse1, Vincent Jaquet2.   

Abstract

NADPH oxidase (NOX) enzymes show great potential as therapeutic pharmacological targets. This Forum revolves around the roles of specific NOX isoforms in oxidative stress-mediated pathologies, available NOX antagonists/agonists as well as the potential side effects of NOX inhibition and the requisite identification of novel oxidative biomarkers as a measure of NOX activity in patients. In addition, an original article reports the discovery of a novel small molecule NOX2 inhibitor. Finally an attractive and innovative therapeutic approach for modulating NOX activity through the inhibition of the proton channel Hv1 is discussed.

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Year:  2015        PMID： 26207329     DOI： 10.1089/ars.2015.6450

Source DB:  PubMed          Journal:  Antioxid Redox Signal        ISSN： 1523-0864            Impact factor:   8.401


  10 in total

1.  High-Throughput Screening of NOX Inhibitors.

Authors:  Jacek Zielonka; Monika Zielonka; Gang Cheng; Micael Hardy; Balaraman Kalyanaraman
Journal:  Methods Mol Biol       Date:  2019

Review 2.  NADPH Oxidases Connecting Fatty Liver Disease, Insulin Resistance and Type 2 Diabetes: Current Knowledge and Therapeutic Outlook.

Authors:  Alberto Nascè; Karim Gariani; François R Jornayvaz; Ildiko Szanto
Journal:  Antioxidants (Basel)       Date:  2022-06-09

Review 3.  Common Shared Pathogenic Aspects of Small Vessels in Heart and Brain Disease.

Authors:  Rita Moretti; Milijana Janjusevic; Alessandra Lucia Fluca; Riccardo Saro; Giulia Gagno; Alessandro Pierri; Laura Padoan; Luca Restivo; Agnese Derin; Antonio Paolo Beltrami; Paola Caruso; Gianfranco Sinagra; Aneta Aleksova
Journal:  Biomedicines       Date:  2022-04-27

Review 4.  Cerebral Small Vessel Disease: Targeting Oxidative Stress as a Novel Therapeutic Strategy?

Authors:  T Michael De Silva; Alyson A Miller
Journal:  Front Pharmacol       Date:  2016-03-17       Impact factor: 5.810

5.  A novel combinatorial technique for simultaneous quantification of oxygen radicals and aggregation reveals unexpected redox patterns in the activation of platelets by different physiopathological stimuli.

Authors:  Dina Vara; Eugenia Cifuentes-Pagano; Patrick J Pagano; Giordano Pula
Journal:  Haematologica       Date:  2019-01-24       Impact factor: 9.941

Review 6.  Understanding Cellular Redox Homeostasis: A Challenge for Precision Medicine.

Authors:  Verena Tretter; Beatrix Hochreiter; Marie Louise Zach; Katharina Krenn; Klaus Ulrich Klein
Journal:  Int J Mol Sci       Date:  2021-12-22       Impact factor: 5.923

7.  RNA-Seq Analyses Reveal Roles of the HVCN1 Proton Channel in Cardiac pH Homeostasis.

Authors:  Xin Wu; Yawei Li; Mark Maienschein-Cline; Leonid Feferman; Longjun Wu; Liang Hong
Journal:  Front Cell Dev Biol       Date:  2022-03-16

Review 8.  Oxidative Stress in Intracerebral Hemorrhage: Sources, Mechanisms, and Therapeutic Targets.

Authors:  Xin Hu; Chuanyuan Tao; Qi Gan; Jun Zheng; Hao Li; Chao You
Journal:  Oxid Med Cell Longev       Date:  2015-12-30       Impact factor: 6.543

Review 9.  Small Vessel Disease-Related Dementia: An Invalid Neurovascular Coupling?

Authors:  Rita Moretti; Paola Caruso
Journal:  Int J Mol Sci       Date:  2020-02-07       Impact factor: 5.923

Review 10.  An Iatrogenic Model of Brain Small-Vessel Disease: Post-Radiation Encephalopathy.

Authors:  Rita Moretti; Paola Caruso
Journal:  Int J Mol Sci       Date:  2020-09-05       Impact factor: 5.923
  10 in total

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