Literature DB >> 26206503

Activity of aminoferrocene-based prodrugs against prostate cancer.

Margot Schikora1, Alexander Reznikov2, Liudmila Chaykovskaya2, Olga Sachinska2, Lubov Polyakova2, Andriy Mokhir3.   

Abstract

We tested cytotoxicity of aminoferrocene-based prodrugs towards human androgen-responsive and unresponsive prostate cancer cell lines LNCaP and DU-145 correspondingly. Two prodrugs were selected, which are both activated at elevated concentrations of ROS with generation of quinone methide (antioxidant system inhibitor) and iron-containing compounds (N-benzylaminoferrocene (prodrug 1) and Fe salts (2)). We observed that only prodrug 1 is active against the selected prostate cancer cells (IC50=11-27 μM) and its activity correlates with the high cell-membrane permeability and increased production of intracellular ROS.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Aminoferrocene; Iron; Prodrug; Prostate cancer; Reactive oxygen species

Mesh：

Substances：

Year:  2015        PMID： 26206503     DOI： 10.1016/j.bmcl.2015.07.013

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

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Review 3.  Chemical Tools for Targeted Amplification of Reactive Oxygen Species in Neutrophils.

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Review 4.  Ferrocene-Based Compounds with Antimalaria/Anticancer Activity.

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Journal:  Cancers (Basel)       Date:  2021-12-31       Impact factor: 6.639

6.  Anticancer Aminoferrocene Derivatives Inducing Production of Mitochondrial Reactive Oxygen Species.

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Review 7.  Redox Control in Acute Lymphoblastic Leukemia: From Physiology to Pathology and Therapeutic Opportunities.

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Journal:  Cells       Date:  2021-05-17       Impact factor: 6.600

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Authors:  Artem Kondratskyi; Kateryna Kondratska; Fabien Vanden Abeele; Dmitri Gordienko; Charlotte Dubois; Robert-Allain Toillon; Christian Slomianny; Sébastien Lemière; Philippe Delcourt; Etienne Dewailly; Roman Skryma; Christophe Biot; Natalia Prevarskaya
Journal:  Sci Rep       Date:  2017-11-21       Impact factor: 4.379

9.  N-Alkylaminoferrocene-Based Prodrugs Targeting Mitochondria of Cancer Cells.

Authors:  Viktor Reshetnikov; Hülya Gizem Özkan; Steffen Daum; Christina Janko; Christoph Alexiou; Caroline Sauer; Markus R Heinrich; Andriy Mokhir
Journal:  Molecules       Date:  2020-05-29       Impact factor: 4.411

Review 10.  Oxidative Stress in the Tumor Microenvironment and Its Relevance to Cancer Immunotherapy.

Authors:  Nada S Aboelella; Caitlin Brandle; Timothy Kim; Zhi-Chun Ding; Gang Zhou
Journal:  Cancers (Basel)       Date:  2021-02-27       Impact factor: 6.639
  10 in total

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