| Literature DB >> 26206000 |
Elena Marcello1, Fabrizio Gardoni1, Monica Di Luca1.
Abstract
This Editorial highlights a study by Baglietto-Vargas et al. 2015 published in this issue of J. Neurochem. Stress is one of the environmental factors that can contribute to Alzheimer's disease pathogenesis. However, the role of modern-life stress has not been investigated yet. The authors reveal that modern-life stress reduces the number of dendritic spines in the hippocampus of Alzheimer's disease transgenic mice. The mechanism underlying such effect involves an increase in corticotropin-releasing hormone (CRH) release that stimulates the amyloid precursor protein (APP) processing and fosters the generation of Amyloid-β, which negatively affects dendritic spines.Entities:
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Year: 2015 PMID: 26206000 DOI: 10.1111/jnc.13210
Source DB: PubMed Journal: J Neurochem ISSN: 0022-3042 Impact factor: 5.372