Literature DB >> 26205346

Bis(monoacylglycero)phosphate as a Macrophage Enriched Phospholipid.

Zeynep Akgoc1, Sonia Iosim, Thomas N Seyfried.   

Abstract

Bis(monoacylglycero)phosphate (BMP) is a structural isomer of phosphatidylglycerol (PtdGro) with an unusual sn-1:sn-1' fatty acyl configuration and is found almost exclusively in late endosomes/lysosomes. BMP comprises only about 1-2% of the total phospholipids in most mammalian cells, but accumulates in tissues of humans and animals with lysosomal storage disorders including the gangliosidoses. Total BMP content was significantly greater in cells of macrophage/microglial origin than in cells of macroglial origin. BMP composition was similar in tumorigenic/metastatic macrophages and non-tumorigenic macrophages/microglia. Finally, BMP fatty acid composition differed between cells grown in culture and obtained in vivo suggesting an influence from growth environment.

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Year:  2015        PMID: 26205346     DOI: 10.1007/s11745-015-4045-5

Source DB:  PubMed          Journal:  Lipids        ISSN: 0024-4201            Impact factor:   1.880


  39 in total

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3.  Lipids of alveolar macrophages, polymorphonuclear leukocytes, and their phagocytic vesicles.

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4.  Ganglioside alterations in stimulated murine macrophages.

Authors:  H C Yohe; D L Coleman; J L Ryan
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5.  N-butyldeoxygalactonojirimycin reduces brain ganglioside and GM2 content in neonatal Sandhoff disease mice.

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7.  A novel pre-clinical in vivo mouse model for malignant brain tumor growth and invasion.

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8.  Subcellular distributions of lipids in cultured BHK cells: evidence for the enrichment of lysobisphosphatidic acid and neutral lipids in lysosomes.

Authors:  J Brotherus; O Renkonen
Journal:  J Lipid Res       Date:  1977-03       Impact factor: 5.922

9.  Metastatic cancer cells with macrophage properties: evidence from a new murine tumor model.

Authors:  Leanne C Huysentruyt; Purna Mukherjee; Dia Banerjee; Laura M Shelton; Thomas N Seyfried
Journal:  Int J Cancer       Date:  2008-07-01       Impact factor: 7.396

10.  Ganglioside distribution in murine neural tumors.

Authors:  T N Seyfried; M el-Abbadi; M L Roy
Journal:  Mol Chem Neuropathol       Date:  1992-10
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  11 in total

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Review 6.  The Emerging and Diverse Roles of Bis(monoacylglycero) Phosphate Lipids in Cellular Physiology and Disease.

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