Ipek Gungor1, Lidia Sarro2, Jonathan Graff-Radford3, Samantha M Zuk4, Nirubol Tosakulwong5, Scott A Przybelski5, Tim Lesnick5, Bradley F Boeve3, Tanis J Ferman6, Glenn E Smith7, David S Knopman3, Massimo Filippi8, Ronald C Petersen3, Clifford R Jack4, Kejal Kantarci9. 1. Department of Radiology, Mayo Clinic, Rochester, MN, USA; Department of Neurology, Istanbul University, Istanbul, Turkey. 2. Department of Radiology, Mayo Clinic, Rochester, MN, USA; Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy. 3. Department of Neurology, Mayo Clinic, Rochester, MN, USA. 4. Department of Radiology, Mayo Clinic, Rochester, MN, USA. 5. Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. 6. Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, USA. 7. Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA. 8. Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy. 9. Department of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address: kantarci.kejal@mayo.edu.
Abstract
AIM: To determine the frequency and topographic distribution of cerebral microbleeds (CMBs) in dementia with Lewy bodies (DLB) in comparison to CMBs in Alzheimer disease dementia (AD). METHODS: Consecutive probable DLB (n = 23) patients who underwent 3-T T2* weighted gradient-recalled-echo MRI, and age and gender matched probable Alzheimer's disease patients (n = 46) were compared for the frequency and location of CMBs. RESULTS: The frequency of one or more CMBs was similar among patients with DLB (30%) and AD (24%). Highest densities of CMBs were found in the occipital lobes of patients with both DLB and AD. Patients with AD had greater densities of CMBs in the parietal, temporal lobes and infratentorial regions compared to DLB (p < 0.05). CONCLUSION: CMBs are as common in patients with DLB as in patients with AD, with highest densities observed in the occipital lobes, suggesting common pathophysiologic mechanisms underlying CMBs in both diseases.
AIM: To determine the frequency and topographic distribution of cerebral microbleeds (CMBs) in dementia with Lewy bodies (DLB) in comparison to CMBs in Alzheimer disease dementia (AD). METHODS: Consecutive probable DLB (n = 23) patients who underwent 3-T T2* weighted gradient-recalled-echo MRI, and age and gender matched probable Alzheimer's diseasepatients (n = 46) were compared for the frequency and location of CMBs. RESULTS: The frequency of one or more CMBs was similar among patients with DLB (30%) and AD (24%). Highest densities of CMBs were found in the occipital lobes of patients with both DLB and AD. Patients with AD had greater densities of CMBs in the parietal, temporal lobes and infratentorial regions compared to DLB (p < 0.05). CONCLUSION:CMBs are as common in patients with DLB as in patients with AD, with highest densities observed in the occipital lobes, suggesting common pathophysiologic mechanisms underlying CMBs in both diseases.
Authors: Keith A Johnson; Matt Gregas; John A Becker; Catherine Kinnecom; David H Salat; Erin K Moran; Erin E Smith; Jonathan Rosand; Dorene M Rentz; William E Klunk; Chester A Mathis; Julie C Price; Steven T Dekosky; Alan J Fischman; Steven M Greenberg Journal: Ann Neurol Date: 2007-09 Impact factor: 10.422
Authors: Kejal Kantarci; Val J Lowe; Bradley F Boeve; Stephen D Weigand; Matthew L Senjem; Scott A Przybelski; Dennis W Dickson; Joseph E Parisi; David S Knopman; Glenn E Smith; Tanis J Ferman; Ronald C Petersen; Clifford R Jack Journal: Neurobiol Aging Date: 2011-10-21 Impact factor: 4.673
Authors: Reisa A Sperling; Clifford R Jack; Sandra E Black; Matthew P Frosch; Steven M Greenberg; Bradley T Hyman; Philip Scheltens; Maria C Carrillo; William Thies; Martin M Bednar; Ronald S Black; H Robert Brashear; Michael Grundman; Eric R Siemers; Howard H Feldman; Rachel J Schindler Journal: Alzheimers Dement Date: 2011-07 Impact factor: 21.566
Authors: Kejal Kantarci; Jeffrey L Gunter; Nirubol Tosakulwong; Stephen D Weigand; Matthew S Senjem; Ronald C Petersen; Paul S Aisen; William J Jagust; Michael W Weiner; Clifford R Jack Journal: Alzheimers Dement Date: 2013-01-30 Impact factor: 21.566
Authors: Jacqueline A Pettersen; Gayathri Sathiyamoorthy; Fu-Qiang Gao; Gregory Szilagyi; Neelesh K Nadkarni; Peter St George-Hyslop; Ekaterina Rogaeva; Sandra E Black Journal: Arch Neurol Date: 2008-06
Authors: M W Vernooij; A van der Lugt; M A Ikram; P A Wielopolski; W J Niessen; A Hofman; G P Krestin; M M B Breteler Journal: Neurology Date: 2008-04-01 Impact factor: 9.910
Authors: Reisa Sperling; Stephen Salloway; David J Brooks; Donatella Tampieri; Jerome Barakos; Nick C Fox; Murray Raskind; Marwan Sabbagh; Lawrence S Honig; Anton P Porsteinsson; Ivan Lieberburg; H Michael Arrighi; Kristen A Morris; Yuan Lu; Enchi Liu; Keith M Gregg; H Robert Brashear; Gene G Kinney; Ronald Black; Michael Grundman Journal: Lancet Neurol Date: 2012-02-03 Impact factor: 44.182
Authors: Paul C Donaghy; Michael Firbank; Dipayan Mitra; George Petrides; Jim Lloyd; Nicola Barnett; Kirsty Olsen; Alan J Thomas; John T O'Brien Journal: J Neurol Date: 2020-02-04 Impact factor: 4.849