Literature DB >> 26204916

From intrinsically disordered protein to context-dependent folding: The α-synuclein tetramer is teased out of hiding.

Thomas C Pochapsky1.   

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Year:  2015        PMID： 26204916      PMCID： PMC4534271          DOI： 10.1073/pnas.1512077112

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


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  16 in total

1.  alpha-Synuclein locus triplication causes Parkinson's disease.

Authors:  A B Singleton; M Farrer; J Johnson; A Singleton; S Hague; J Kachergus; M Hulihan; T Peuralinna; A Dutra; R Nussbaum; S Lincoln; A Crawley; M Hanson; D Maraganore; C Adler; M R Cookson; M Muenter; M Baptista; D Miller; J Blancato; J Hardy; K Gwinn-Hardy
Journal:  Science       Date:  2003-10-31       Impact factor: 47.728

2.  A soluble α-synuclein construct forms a dynamic tetramer.

Authors:  Wei Wang; Iva Perovic; Johnathan Chittuluru; Alice Kaganovich; Linh T T Nguyen; Jingling Liao; Jared R Auclair; Derrick Johnson; Anuradha Landeru; Alana K Simorellis; Shulin Ju; Mark R Cookson; Francisco J Asturias; Jeffrey N Agar; Brian N Webb; Chulhee Kang; Dagmar Ringe; Gregory A Petsko; Thomas C Pochapsky; Quyen Q Hoang
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-17       Impact factor: 11.205

3.  Structure and dynamics of micelle-bound human alpha-synuclein.

Authors:  Tobias S Ulmer; Ad Bax; Nelson B Cole; Robert L Nussbaum
Journal:  J Biol Chem       Date:  2004-12-22       Impact factor: 5.157

4.  α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.

Authors:  Bruno Fauvet; Martial K Mbefo; Mohamed-Bilal Fares; Carole Desobry; Sarah Michael; Mustafa T Ardah; Elpida Tsika; Philippe Coune; Michel Prudent; Niels Lion; David Eliezer; Darren J Moore; Bernard Schneider; Patrick Aebischer; Omar M El-Agnaf; Eliezer Masliah; Hilal A Lashuel
Journal:  J Biol Chem       Date:  2012-02-07       Impact factor: 5.157

5.  αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction.

Authors:  Becket Greten-Harrison; Manuela Polydoro; Megumi Morimoto-Tomita; Ling Diao; Andrew M Williams; Esther H Nie; Sachin Makani; Ning Tian; Pablo E Castillo; Vladimir L Buchman; Sreeganga S Chandra
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-25       Impact factor: 11.205

6.  Alpha-synuclein in Lewy bodies.

Authors:  M G Spillantini; M L Schmidt; V M Lee; J Q Trojanowski; R Jakes; M Goedert
Journal:  Nature       Date:  1997-08-28       Impact factor: 49.962

7.  The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system.

Authors:  A Iwai; E Masliah; M Yoshimoto; N Ge; L Flanagan; H A de Silva; A Kittel; T Saitoh
Journal:  Neuron       Date:  1995-02       Impact factor: 17.173

8.  Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR.

Authors:  Henrike Heise; Wolfgang Hoyer; Stefan Becker; Ovidiu C Andronesi; Dietmar Riedel; Marc Baldus
Journal:  Proc Natl Acad Sci U S A       Date:  2005-10-24       Impact factor: 11.205

9.  Synphilin-1 inhibits alpha-synuclein degradation by the proteasome.

Authors:  Beatriz Alvarez-Castelao; José G Castaño
Journal:  Cell Mol Life Sci       Date:  2010-11-20       Impact factor: 9.261

10.  α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation.

Authors:  Tim Bartels; Joanna G Choi; Dennis J Selkoe
Journal:  Nature       Date:  2011-08-14       Impact factor: 49.962
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  3 in total

Review 1.  Navigating the dynamic landscape of alpha-synuclein morphology: a review of the physiologically relevant tetrameric conformation.

Authors:  Heather R Lucas; Ricardo D Fernández
Journal:  Neural Regen Res       Date:  2020-03       Impact factor: 5.135

Review 2.  Soluble endogenous oligomeric α-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk.

Authors:  Rakez Kayed; Ulf Dettmer; Sylvain E Lesné
Journal:  J Parkinsons Dis       Date:  2020       Impact factor: 5.568

3.  Potent inhibitors of toxic alpha-synuclein identified via cellular time-resolved FRET biosensors.

Authors:  Anthony R Braun; Elly E Liao; Mian Horvath; Prakriti Kalra; Karen Acosta; Malaney C Young; Noah Nathan Kochen; Chih Hung Lo; Roland Brown; Michael D Evans; William C K Pomerantz; Elizabeth Rhoades; Kelvin Luk; Razvan L Cornea; David D Thomas; Jonathan N Sachs
Journal:  NPJ Parkinsons Dis       Date:  2021-06-28
  3 in total

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