Heba Alwan1, Georg Ehret, Belen Ponte, Menno Pruijm, Daniel Ackermann, Idris Guessous, Jan A Staessen, Kei Asayama, Zoltán Kutalik, Philippe Vuistiner, Fred Paccaud, Antoinette Pechere-Bertschi, Markus Mohaupt, Bruno Vogt, Pierre-Yves Martin, Michel Burnier, Murielle Bochud. 1. aInstitute of Social and Preventive Medicine (IUMSP), University Hospital of Lausanne, Lausanne bDepartment of Cardiology cService of Nephrology, Department of Specialties, University Hospital of Geneva, Geneva dService of Nephrology, University Hospital of Lausanne, Lausanne eDepartment of Nephrology, Hypertension and Clinical Pharmacology, Inselspital, Bern University Hospital and University of Bern, Bern fUnit of Population Epidemiology, University Hospital of Geneva, Geneva, Switzerland gStudies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium hDepartment of Epidemiology, Maastricht University, Maastricht, the Netherlands iDepartment of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Japan jSwiss Institute of Bioinformatics, University of Lausanne, Lausanne kDepartment of Community Medicine and Primary Care and Emergency Medicine, University Hospital of Geneva, Geneva, Switzerland.
Abstract
BACKGROUND: Blood pressure (BP) is known to aggregate in families. Yet, heritability estimates are population-specific and no Swiss data have been published so far. We estimated the heritability of ambulatory and office BP in a Swiss population-based sample. METHODS: The Swiss Kidney Project on Genes in Hypertension is a population-based family study focusing on BP genetics. Office and ambulatory BP were measured in 1009 individuals from 271 nuclear families. Heritability was estimated for SBP, DBP, and pulse pressure using a maximum likelihood method implanted in the Statistical Analysis in Genetic Epidemiology software. RESULTS: The 518 women and 491 men included in this analysis had a mean (±SD) age of 48.3 (±17.4) and 47.3 (±17.7) years, and a mean BMI of 23.8 (±4.2) and 25.9 (±4.1) kg/m, respectively. Narrow-sense heritability estimates (±standard error) for ambulatory SBP, DBP, and pulse pressure were 0.37 ± 0.07, 0.26 ± 0.07, and 0.29 ± 0.07 for 24-h BP; 0.39 ± 0.07, 0.28 ± 0.07, and 0.27 ± 0.07 for day BP; and 0.25 ± 0.07, 0.20 ± 0.07, and 0.30 ± 0.07 for night BP, respectively (all P < 0.001). Heritability estimates for office SBP, DBP, and pulse pressure were 0.21 ± 0.08, 0.25 ± 0.08, and 0.18 ± 0.07 (all P < 0.01). CONCLUSIONS: We found significant heritability estimates for both ambulatory and office BP in this Swiss population-based study. Our findings justify the ongoing search for the genetic determinants of BP.
BACKGROUND: Blood pressure (BP) is known to aggregate in families. Yet, heritability estimates are population-specific and no Swiss data have been published so far. We estimated the heritability of ambulatory and office BP in a Swiss population-based sample. METHODS: The Swiss Kidney Project on Genes in Hypertension is a population-based family study focusing on BP genetics. Office and ambulatory BP were measured in 1009 individuals from 271 nuclear families. Heritability was estimated for SBP, DBP, and pulse pressure using a maximum likelihood method implanted in the Statistical Analysis in Genetic Epidemiology software. RESULTS: The 518 women and 491 men included in this analysis had a mean (±SD) age of 48.3 (±17.4) and 47.3 (±17.7) years, and a mean BMI of 23.8 (±4.2) and 25.9 (±4.1) kg/m, respectively. Narrow-sense heritability estimates (±standard error) for ambulatory SBP, DBP, and pulse pressure were 0.37 ± 0.07, 0.26 ± 0.07, and 0.29 ± 0.07 for 24-h BP; 0.39 ± 0.07, 0.28 ± 0.07, and 0.27 ± 0.07 for day BP; and 0.25 ± 0.07, 0.20 ± 0.07, and 0.30 ± 0.07 for night BP, respectively (all P < 0.001). Heritability estimates for office SBP, DBP, and pulse pressure were 0.21 ± 0.08, 0.25 ± 0.08, and 0.18 ± 0.07 (all P < 0.01). CONCLUSIONS: We found significant heritability estimates for both ambulatory and office BP in this Swiss population-based study. Our findings justify the ongoing search for the genetic determinants of BP.
Authors: Justin R Ryder; Nathan D Pankratz; Donald R Dengel; James S Pankow; David R Jacobs; Alan R Sinaiko; Vasu Gooty; Julia Steinberger Journal: J Am Heart Assoc Date: 2017-02-02 Impact factor: 5.501
Authors: Tengfei Man; Ilja M Nolte; Deepali Jaju; Zahir A M Al-Anqoudi; M Loretto Muñoz; Mohammed O Hassan; Said Al-Yahyaee; Riad A Bayoumi; Anthony G Comuzzie; John S Floras; Arie M van Roon; Harriëtte Riese; Sulayma Albarwani; Harold Snieder Journal: J Hypertens Date: 2020-08 Impact factor: 4.776