Giovanna Ferraioli1, Carmine Tinelli2, Raffaella Lissandrin3, Mabel Zicchetti3, Mariangela Rondanelli4, Guido Perani5, Stefano Bernuzzi6, Laura Salvaneschi6, Carlo Filice3. 1. Ultrasound Unit, Department of Infectious Diseases, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Via Taramelli 5, 27100, Pavia, Italy. giovanna.ferraioli@unipv.it. 2. Clinical Epidemiology and Biometric Unit, Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, 27100, Pavia, Italy. 3. Ultrasound Unit, Department of Infectious Diseases, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Via Taramelli 5, 27100, Pavia, Italy. 4. Department of Applied Health Sciences, Istituto di Cura "Santa Margherita", University of Pavia, Via Emilia 12, 27100, Pavia, Italy. 5. Department of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, 27100, Pavia, Italy. 6. Department of "Medicina Diagnostica e dei Servizi", Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, 27100, Pavia, Italy.
Abstract
PURPOSE: This study was conducted to prospectively investigate the interobserver reproducibility of controlled attenuation parameter (CAP) measurements and the relationship among the CAP and body mass index (BMI), gender and age. METHODS: Consecutive subjects were studied using the M+ probe of the FibroScan device (Echosens, Paris, France). Measurements were performed by two raters (rater1 and rater2). Interobserver agreement was assessed by using the concordance correlation coefficient (CCC). The Pearson r coefficient was used to test correlation between two study variables, and linear regression was used for the multivariate model. RESULTS: Three hundred fifty-one subjects (227 males and 124 females) were prospectively studied. The CCC was 0.82 (95 % CI 0.78-0.85) overall, 0.80 (95 % CI 0.75-0.85) for BMI <25 kg/m(2), 0.76 (95 % CI 0.69-0.84) for BMI 25-29 kg/m(2) and 0.65 (95 % CI 0.41-0.88) for BMI ≥30 kg/m(2). The CCC was 0.44 (95 % CI 0.31-0.56) for CAP values ≤240 dB/m and 0.72 (95 % CI 0.65-0.79) for CAP values >240 dB/m. In univariate analysis, age and BMI by gender were correlated with the CAP. Multiple regression analysis confirmed the relationship of the CAP with age and BMI, but not with gender. CONCLUSIONS: The results of this study show that the interreader agreement in CAP measurement is good. In healthy volunteers, the CAP is strongly correlated with age and BMI.
PURPOSE: This study was conducted to prospectively investigate the interobserver reproducibility of controlled attenuation parameter (CAP) measurements and the relationship among the CAP and body mass index (BMI), gender and age. METHODS: Consecutive subjects were studied using the M+ probe of the FibroScan device (Echosens, Paris, France). Measurements were performed by two raters (rater1 and rater2). Interobserver agreement was assessed by using the concordance correlation coefficient (CCC). The Pearson r coefficient was used to test correlation between two study variables, and linear regression was used for the multivariate model. RESULTS: Three hundred fifty-one subjects (227 males and 124 females) were prospectively studied. The CCC was 0.82 (95 % CI 0.78-0.85) overall, 0.80 (95 % CI 0.75-0.85) for BMI <25 kg/m(2), 0.76 (95 % CI 0.69-0.84) for BMI 25-29 kg/m(2) and 0.65 (95 % CI 0.41-0.88) for BMI ≥30 kg/m(2). The CCC was 0.44 (95 % CI 0.31-0.56) for CAP values ≤240 dB/m and 0.72 (95 % CI 0.65-0.79) for CAP values >240 dB/m. In univariate analysis, age and BMI by gender were correlated with the CAP. Multiple regression analysis confirmed the relationship of the CAP with age and BMI, but not with gender. CONCLUSIONS: The results of this study show that the interreader agreement in CAP measurement is good. In healthy volunteers, the CAP is strongly correlated with age and BMI.
Authors: M Sasso; I Tengher-Barna; M Ziol; V Miette; C Fournier; L Sandrin; R Poupon; A-C Cardoso; P Marcellin; C Douvin; V de Ledinghen; J-C Trinchet; M Beaugrand Journal: J Viral Hepat Date: 2011-10-13 Impact factor: 3.728
Authors: Max M Puthenpura; Vishal Patel; John Fam; Leon Katz; David S Tichansky; Stephan Myers Journal: Obes Surg Date: 2020-09-26 Impact factor: 4.129
Authors: Giovanna Ferraioli; Laura Maiocchi; Maria Vittoria Raciti; Carmine Tinelli; Annalisa De Silvestri; Mara Nichetti; Pasquale De Cata; Mariangela Rondanelli; Luca Chiovato; Fabrizio Calliada; Carlo Filice Journal: Clin Transl Gastroenterol Date: 2019-10 Impact factor: 4.488