| Literature DB >> 26202575 |
Sanae Saka1,2, Nobuhito Hirawa2, Akira Oka3, Keisuke Yatsu1, Takeshi Hirukawa4, Ryohei Yamamoto5, Taiji Matsusaka4, Enyu Imai6,7, Ichiei Narita8, Masayuki Endoh4, Iekuni Ichikawa9,10, Satoshi Umemura1, Hidetoshi Inoko3.
Abstract
Immunoglobulin A nephropathy (IgAN) is the most common form of primary glomerulonephritis in many parts of the world. Although previous genome-wide association studies (GWAS) identified the major susceptibility loci for IgAN, the causal genes currently remain unknown. We performed a GWAS using 23 465 microsatellite (MS) markers to identify genes related to IgAN in a Japanese population. A pooled sample analysis was conducted in three-stage screenings of three independent case-control populations, and after the final step of individual typing, 11 markers survived. Of these, we focused on two regions on 6p21 and 12q21 because they (i) showed the strongest relationship with IgAN, and (ii) appeared to be highly relevant to IgAN in view of several previous studies. These regions contained the HLA, TSPAN8 and PTPRR genes. This study on GWAS, using >20 000 MS markers, provides a new approach regarding susceptible genes for IgAN for investigators seeking new tools for the prevention and treatment of IgAN.Entities:
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Year: 2015 PMID： 26202575 DOI： 10.1038/jhg.2015.88
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172