| Literature DB >> 26202544 |
Andrew Binder1, Asghar Ali, Raveen Chawla, Hammad A Aziz, Antonio Abbate, Ion S Jovin.
Abstract
Effective primary and secondary prevention and advances in cardiac surgery have significantly improved the care and outcomes of patients with myocardial ischemia. While timely reperfusion has proved to be an invaluable tool, ischemia-reperfusion injury represents a mechanism that may limit its effectiveness. Numerous experimental studies have shown effective protection from ischemia-reperfusion injury in animal models, but translation into clinical practice has been less successful. This article summarizes the role of ischemia-reperfusion injury in the pathophysiology of ischemic heart disease and gives an overview of the various modalities that have been developed in order to provide myocardial protection from reperfusion injury in clinical practice.Entities:
Keywords: acute myocardial infarction; cardiac surgery; ischemia–reperfusion injury; myocardial protection; percutaneous coronary intervention; postconditioning; preconditioning
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Year: 2015 PMID： 26202544 DOI： 10.1586/14779072.2015.1070669
Source DB: PubMed Journal: Expert Rev Cardiovasc Ther ISSN： 1477-9072