INTRODUCTION: Magnetic stimulation (MS) has the ability to induce muscle twitch and has long been proposed as a therapeutic modality for skeletal muscle diseases. However, the molecular mechanisms underlying its means of action have not been defined. METHODS: Muscle regeneration after trauma was studied in a standard muscle injury mouse model. The influence of MS on the formation of motor units, posttrauma muscle/nerve regeneration, and vascularization was investigated. RESULTS: We found that MS does not cause systemic or muscle damage but improves muscle regeneration by significantly minimizing the presence of inflammatory infiltrate and formation of scars after trauma. It avoids posttrauma muscle atrophy, induces muscle hypertrophy, and increases the metabolism and turnover of muscle. It triples the expression of muscle markers and significantly improves muscle functional recovery after trauma. CONCLUSIONS: Our results indicate that MS supports muscle and nerve regeneration by activating muscle-nerve cross-talk and inducing the maturation of neuromuscular junctions.
INTRODUCTION: Magnetic stimulation (MS) has the ability to induce muscle twitch and has long been proposed as a therapeutic modality for skeletal muscle diseases. However, the molecular mechanisms underlying its means of action have not been defined. METHODS: Muscle regeneration after trauma was studied in a standard muscle injury mouse model. The influence of MS on the formation of motor units, posttrauma muscle/nerve regeneration, and vascularization was investigated. RESULTS: We found that MS does not cause systemic or muscle damage but improves muscle regeneration by significantly minimizing the presence of inflammatory infiltrate and formation of scars after trauma. It avoids posttrauma muscle atrophy, induces muscle hypertrophy, and increases the metabolism and turnover of muscle. It triples the expression of muscle markers and significantly improves muscle functional recovery after trauma. CONCLUSIONS: Our results indicate that MS supports muscle and nerve regeneration by activating muscle-nerve cross-talk and inducing the maturation of neuromuscular junctions.
Authors: Jens Stern-Straeter; Gabriel Alejandro Bonaterra; Stefan S Kassner; Anne Faber; Alexander Sauter; Johannes D Schulz; Karl Hörmann; Ralf Kinscherf; Ulrich Reinhart Goessler Journal: Int J Mol Med Date: 2011-08-11 Impact factor: 4.101
Authors: Dario Coletti; Laura Teodori; Maria C Albertini; Marco Rocchi; Alessandro Pristerà; Massimo Fini; Mario Molinaro; Sergio Adamo Journal: Cytometry A Date: 2007-10 Impact factor: 4.355
Authors: Maria Laura Lopes de Carvalho; Roberta Motta; Giovanna Konrad; Mario Alberto Battaglia; Giampaolo Brichetto Journal: Mult Scler Date: 2011-07-25 Impact factor: 6.312
Authors: Petra J Voorham-van der Zalm; Rob C M Pelger; Anne M Stiggelbout; Henk W Elzevier; Guus A B Lycklama à Nijeholt Journal: BJU Int Date: 2006-05 Impact factor: 5.588
Authors: X N Wang; T J Williams; M J McKenna; J L Li; S F Fraser; E A Side; G I Snell; E H Walters; M F Carey Journal: Am J Respir Crit Care Med Date: 1999-07 Impact factor: 21.405
Authors: Samuel Sorkhi; Christopher Cano Sanchez; Min Chul Cho; Sung Yong Cho; Hong Chung; Min Gu Park; Susan Lahey; Tung-Chin Hsieh; Valmik Bhargava; Mahadevan Raj Rajasekaran Journal: World J Mens Health Date: 2022-01-02 Impact factor: 6.494