Detecting fibrosis without a liver biopsy: getting to the fat of the issue.

It is critical to assess the degree of liver fibrosis for clinical management. However, liver biopsy has many drawbacks and is invasive. Promising non-invasive methods including serum markers and new imaging studies to predict liver fibrosis have been developed in past decades. This editorial provides a succinct overview and update of the new non-invasive technologies, especially the three-dimensional magnetic resonance imaging (3-D MRI) that has been studied by Dr. Kawamura's group in Japan. It also highlights the merit and weakness of this 3D-MRI technology in predicting liver fibrosis and indicates future studies to understand where 3D-MRI fits into the current armamentarium of non-invasive serum-based and imaging technologies.