| Literature DB >> 26201501 |
Jaewook Lee1, Si-Hyun Kim1, Dong-Sic Choi1, Jong Seok Lee2, Dae-Kyum Kim1, Gyeongyun Go1, Seon-Min Park3, Si Hyun Kim4,5, Jeong Hwan Shin4,5, Chulhun L Chang6,7, Yong Song Gho1.
Abstract
The release of extracellular vesicles, also known as outer membrane vesicles, membrane vesicles, exosomes, and microvesicles, is an evolutionarily conserved phenomenon from bacteria to eukaryotes. It has been reported that Mycobacterium tuberculosis releases extracellular vesicles harboring immunologically active molecules, and these extracellular vesicles have been suggested to be applicable in vaccine development and biomarker discovery. However, the comprehensive proteomic analysis has not been performed for M. tuberculosis extracellular vesicles. In this study, we identified a total of 287 vesicular proteins by four LC-MS/MS analyses with high confidence. In addition, we identified several vesicular proteins associated with the virulence of M. tuberculosis. This comprehensive proteome profile will help elucidate the pathogenic mechanism of M. tuberculosis. The data have been deposited to the ProteomeXchange with identifier PXD001160 (http://proteomecentral.proteomexchange.org/dataset/PXD001160).Entities:
Keywords: Diagnosis; Extracellular vesicles; Microbiology; Mycobacterium tuberculosis
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Year: 2015 PMID： 26201501 DOI： 10.1002/pmic.201500037
Source DB: PubMed Journal: Proteomics ISSN： 1615-9853 Impact factor: 3.984