Min Zhang1, Yan Zhong1, Jun Chen2. 1. Liver Diseases Center, The Second Xiangya Hospital, Changsha, 410011, China. 2. Liver Diseases Center, The Second Xiangya Hospital, Changsha, 410011, China. drchenjun@yahoo.com.cn.
Abstract
BACKGROUND: Hepatic stem cells are capable to self-renew and to differentiate into all types of cells in the liver, including hepatic progenitors, mature hepatocytes and cholangiocytes. AIMS: This review summarizes the recent advances in animal studies and the results of clinical trials over the last few decades. RESULTS: Studies in numerous animal models of liver diseases have demonstrated the efficacy of hepatic stem cells. Clinical studies of hepatic stem cells are also promising for a variety of hepatic diseases. CONCLUSIONS: With the accumulation of innovative and creative works, hepatic stem cells therapy will be a new approach for liver diseases.
BACKGROUND: Hepatic stem cells are capable to self-renew and to differentiate into all types of cells in the liver, including hepatic progenitors, mature hepatocytes and cholangiocytes. AIMS: This review summarizes the recent advances in animal studies and the results of clinical trials over the last few decades. RESULTS: Studies in numerous animal models of liver diseases have demonstrated the efficacy of hepatic stem cells. Clinical studies of hepatic stem cells are also promising for a variety of hepatic diseases. CONCLUSIONS: With the accumulation of innovative and creative works, hepatic stem cells therapy will be a new approach for liver diseases.
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