Sara Rahati1, Mohammadreza Eshraghian2, Abdolali Ebrahimi3, Hamideh Pishva1. 1. Department of Cellular-Molecular Nutrition, School of Nutrition, Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. 2. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. 3. Department of Pathology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract
BACKGROUND: Chronic ulcer is still a serious issue for diabetic patients. Diabetes is a prevalent cause of ulcer regeneration delay and (or) disruption. Since Spinacia oleracea extract contains compounds with anti-oxidative and anti-inflammatory effects, this may be effective in accelerating the healing process of ulcers, especially diabetic ulcers. Hence, this study examined the effect of Spinacia oleracea aqueous extract on ulcer regeneration in an experimental animal model. RESULTS: Macroscopic examination of the wounds of the control group and spinach aqueous extract group between 7 and 21 days compared with diabetic group, significant changes were observed (P < 0.05). On microscopic examination, epithelial tissue formation, formation of granulation tissue and new blood vessels in the spinach aqueous extract group and non-diabetic group compared to the diabetic group showed significant improvements (P < 0.05). Also, significant differences in vascular endothelial growth factor were observed between groups on days 3 and 7 (P < 0.05). CONCLUSION: The Spinacia oleracea aqueous extract can be effective in regenerating diabetic ulcers. It affects the speed and structure of the ulcer.
BACKGROUND: Chronic ulcer is still a serious issue for diabeticpatients. Diabetes is a prevalent cause of ulcer regeneration delay and (or) disruption. Since Spinacia oleracea extract contains compounds with anti-oxidative and anti-inflammatory effects, this may be effective in accelerating the healing process of ulcers, especially diabetic ulcers. Hence, this study examined the effect of Spinacia oleracea aqueous extract on ulcer regeneration in an experimental animal model. RESULTS: Macroscopic examination of the wounds of the control group and spinach aqueous extract group between 7 and 21 days compared with diabetic group, significant changes were observed (P < 0.05). On microscopic examination, epithelial tissue formation, formation of granulation tissue and new blood vessels in the spinach aqueous extract group and non-diabetic group compared to the diabetic group showed significant improvements (P < 0.05). Also, significant differences in vascular endothelial growth factor were observed between groups on days 3 and 7 (P < 0.05). CONCLUSION: The Spinacia oleracea aqueous extract can be effective in regenerating diabetic ulcers. It affects the speed and structure of the ulcer.
Authors: Gholam Hossein Farjah; Masoumeh Mohammad Pour; Mohammad Hassan Khadem-Ansari; Mojtaba Karimipour; Bagher Pourheidar Journal: Vet Res Forum Date: 2018-06-15 Impact factor: 1.054