P Gorphe1, P Blanchard2, I Breuskin1, S Temam1, Y Tao2, F Janot2. 1. Department of Head and Neck Oncology,Institut Gustave Roussy,Villejuif,France. 2. Department of Radiotherapy,Institut Gustave Roussy,Villejuif,France.
Abstract
OBJECTIVE: This study aimed to assess the influence of supra- and subglottic extensions and vocal fold mobility on outcome in a large monocentric cohort of 148 patients treated for tumour-node-metastasis stage T2N0 glottic carcinomas. METHODS: In all, 107 glottic carcinoma patients had normal vocal fold mobility (T2aN0), and 41 had impaired vocal fold mobility (T2bN0). Treatment decisions were made by a multidisciplinary team. RESULTS: Vocal fold mobility was associated with overall survival, disease-free survival, local control, larynx preservation and laryngectomy-free survival. For patients with T2a lesions, local control, laryngectomy-free survival and disease-free survival improved after surgery but overall survival did not. For patients with T2b lesions, local control, laryngectomy-free survival, disease-free survival and overall survival were all higher after surgery than after radiotherapy. CONCLUSION: This study highlights for the first time the importance of vocal fold mobility in treatment outcomes and is the first to assess its influence on survival. Updated tumour-node-metastasis classifications should consider the distinction between T2a and T2b lesions.
OBJECTIVE: This study aimed to assess the influence of supra- and subglottic extensions and vocal fold mobility on outcome in a large monocentric cohort of 148 patients treated for tumour-node-metastasis stage T2N0 glottic carcinomas. METHODS: In all, 107 glottic carcinomapatients had normal vocal fold mobility (T2aN0), and 41 had impaired vocal fold mobility (T2bN0). Treatment decisions were made by a multidisciplinary team. RESULTS: Vocal fold mobility was associated with overall survival, disease-free survival, local control, larynx preservation and laryngectomy-free survival. For patients with T2a lesions, local control, laryngectomy-free survival and disease-free survival improved after surgery but overall survival did not. For patients with T2b lesions, local control, laryngectomy-free survival, disease-free survival and overall survival were all higher after surgery than after radiotherapy. CONCLUSION: This study highlights for the first time the importance of vocal fold mobility in treatment outcomes and is the first to assess its influence on survival. Updated tumour-node-metastasis classifications should consider the distinction between T2a and T2b lesions.
Authors: Cesare Piazza; Marta Filauro; Alberto Paderno; Filippo Marchi; Pietro Perotti; Riccardo Morello; Stefano Taboni; Giampiero Parrinello; Fabiola Incandela; Andrea Iandelli; Francesco Missale; Giorgio Peretti Journal: Front Oncol Date: 2018-05-22 Impact factor: 6.244
Authors: Martine Hendriksma; Marc A P van Ruler; Berit M Verbist; Martin A de Jong; Ton P M Langeveld; Peter Paul G van Benthem; Elisabeth V Sjögren Journal: Cancers (Basel) Date: 2019-09-06 Impact factor: 6.639