Literature DB >> 26201048

Simultaneous solvent screening and reaction optimization in microliter slugs.

Brandon J Reizman1, Klavs F Jensen.   

Abstract

An automated, continuous flow droplet screening system is presented, enabling real-time simultaneous solvent and continuous variable optimization. An optimal design of experiments strategy is applied to the alkylation of 1,2-diaminocyclohexane in 16 μL droplets, with scale-up demonstrated. Analysis of segmented flow results suggests correlation of yield with solvent hydrogen bond basicity.

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Year:  2015        PMID： 26201048     DOI： 10.1039/c5cc03651h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

Review 1.  Potential Applications of Artificial Intelligence and Machine Learning in Radiochemistry and Radiochemical Engineering.

Authors:  E William Webb; Peter J H Scott
Journal:  PET Clin       Date:  2021-10

2.  Suzuki-Miyaura cross-coupling optimization enabled by automated feedback.

Authors:  Brandon J Reizman; Yi-Ming Wang; Stephen L Buchwald; Klavs F Jensen
Journal:  React Chem Eng       Date:  2016-10-18       Impact factor: 4.239

3.  Automation and Microfluidics for the Efficient, Fast, and Focused Reaction Development of Asymmetric Hydrogenation Catalysis.

Authors:  Robbert van Putten; Natalie S Eyke; Lorenz M Baumgartner; Victor L Schultz; Georgy A Filonenko; Klavs F Jensen; Evgeny A Pidko
Journal:  ChemSusChem       Date:  2022-06-03       Impact factor: 9.140

Review 4.  Self-Driving Laboratories for Development of New Functional Materials and Optimizing Known Reactions.

Authors:  Mikhail A Soldatov; Vera V Butova; Danil Pashkov; Maria A Butakova; Pavel V Medvedev; Andrey V Chernov; Alexander V Soldatov
Journal:  Nanomaterials (Basel)       Date:  2021-03-02       Impact factor: 5.076
  4 in total

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