Philipe de Souto Barreto1,2, Sandrine Andrieu1,2, Pierre Payoux3,4, Laurent Demougeot1, Yves Rolland1,2, Bruno Vellas1,2. 1. Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital, Centre Hospitalier Universitaire Toulouse, Toulouse, France. 2. UMR INSERM 1027, University of Toulouse III, Toulouse, France. 3. UMR 825, University of Toulouse III, Toulouse, France. 4. Department of Nuclear Medicine, University Hospital of Toulouse (CHU-Toulouse), Toulouse, France.
Abstract
OBJECTIVES: To examine the associations between amyloid-β brain deposition and physical activity (PA) in elderly adults without dementia and to investigate whether the association has a dose-response relationship. DESIGN: Cross-sectional study. SETTING:French community-dwelling people. PARTICIPANTS: Elderly adults with normal or mildly impaired cognition (mean age 74.7 ± 4.2; 60.4% female) with available information on current self-reported PA and amyloid-β brain deposition measured using positron emission tomography (PET) using the PET-ligand florbetapir F 18 (n = 268). MEASUREMENTS: A standardized uptake value ratio (SUVR) was obtained for each subject. Participants were divided according to amyloid plaque cortical retention defined according to a SUVR cutoff of 1.10 (SUVR+ vs SUVR-). RESULTS: Bivariate and multivariate analyses showed that PA was not significantly associated with SUVR. SUVR+ and SUVR- participants did not differ in terms of volume (continuous PA variables) and levels (categorical PA variables) of PA. PA was not correlated with SUVR in apolipoprotein E ε4 carriers or noncarriers. PA was not associated with cognitive function. CONCLUSION: Although PA protects against dementia, there is no solid evidence that this protection involves a reduction in amyloid-β brain deposition. Further studies are needed to determine whether PA (ideally measured at several time-points using objective measures) is involved in the pathophysiology of Alzheimer's disease.
RCT Entities:
OBJECTIVES: To examine the associations between amyloid-β brain deposition and physical activity (PA) in elderly adults without dementia and to investigate whether the association has a dose-response relationship. DESIGN: Cross-sectional study. SETTING: French community-dwelling people. PARTICIPANTS: Elderly adults with normal or mildly impaired cognition (mean age 74.7 ± 4.2; 60.4% female) with available information on current self-reported PA and amyloid-β brain deposition measured using positron emission tomography (PET) using the PET-ligand florbetapir F 18 (n = 268). MEASUREMENTS: A standardized uptake value ratio (SUVR) was obtained for each subject. Participants were divided according to amyloid plaque cortical retention defined according to a SUVR cutoff of 1.10 (SUVR+ vs SUVR-). RESULTS: Bivariate and multivariate analyses showed that PA was not significantly associated with SUVR. SUVR+ and SUVR- participants did not differ in terms of volume (continuous PA variables) and levels (categorical PA variables) of PA. PA was not correlated with SUVR in apolipoprotein E ε4 carriers or noncarriers. PA was not associated with cognitive function. CONCLUSION: Although PA protects against dementia, there is no solid evidence that this protection involves a reduction in amyloid-β brain deposition. Further studies are needed to determine whether PA (ideally measured at several time-points using objective measures) is involved in the pathophysiology of Alzheimer's disease.
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