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Literature DB >> 26200323

Universal Fluorescence Biosensor Platform Based on Graphene Quantum Dots and Pyrene-Functionalized Molecular Beacons for Detection of MicroRNAs.

Huan Zhang¹, Yunsheng Wang², Daiwei Zhao², Dongdong Zeng¹, Jiaoyun Xia^3,4, Ali Aldalbahi⁵, Chenguang Wang¹, Lili San¹, Chunhai Fan⁴, Xiaolei Zuo⁴, Xianqiang Mi¹.

Abstract

A novel biosensor platform was developed for detection of microRNAs (miRNAs) based on graphene quantum dots (GQDs) and pyrene-functionalized molecular beacon probes (py-MBs). Pyrene was introduced to trigger specifically fluorescence resonance energy transfer (FRET) between GQDs and fluorescent dyes labeled on py-MBs, and the unique fluorescent intensity change produced a novel signal for detection of the target. The platform realized detection of miRNAs in a wide range from 0.1 nM to 200 nM with great discrimination abilities, as well as multidetection of different kinds of miRNAs, which paved a brand new way for miRNA detection based on GQDs.

Entities: Chemical

Keywords: biosensor; fluorescence resonance energy transfer; graphene quantum dots; microRNA; pyrene

Mesh：

Substances：

Year: 2015 PMID： 26200323 DOI： 10.1021/acsami.5b04773

Source DB: PubMed Journal: ACS Appl Mater Interfaces ISSN： 1944-8244 Impact factor: 9.229

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Cited

16 in total

1. A highly sensitive and selective signal-on strategy for microRNA quantification.

Authors: Li Pan; Huaisheng Zhang; Jingjin Zhao; Xiangtang Li; Rui Xu; Yinyuan Mo; Paul B Tchounwou; Yi-Ming Liu
Journal: Anal Chim Acta Date: 2019-12-03 Impact factor: 6.558

2. MoS₂ quantum dots modified with a labeled molecular beacon as a ratiometric fluorescent gene probe for FRET based detection and imaging of microRNA.

Authors: Xinsheng Yu; Lianzhe Hu; Feng Zhang; Min Wang; Zhining Xia; Weili Wei
Journal: Mikrochim Acta Date: 2018-03-27 Impact factor: 5.833

Review 3. Applications of Graphene Quantum Dots in Biomedical Sensors.

Authors: Bhargav D Mansuriya; Zeynep Altintas
Journal: Sensors (Basel) Date: 2020-02-16 Impact factor: 3.576

Review 4. Graphene quantum dots: synthesis, properties, and applications to the development of optical and electrochemical sensors for chemical sensing.

Authors: Noel Nesakumar; Soorya Srinivasan; Subbiah Alwarappan
Journal: Mikrochim Acta Date: 2022-06-15 Impact factor: 5.833

5. Ultrasensitive fluorescence detection of microRNA through DNA-induced assembly of carbon dots on gold nanoparticles with no signal amplification strategy.

Authors: Mengyuan He; Ning Shang; Bo Zheng; Gege Yue; Xi Han; Xuebo Hu
Journal: Mikrochim Acta Date: 2022-05-10 Impact factor: 5.833

Universal Fluorescence Biosensor Platform Based on Graphene Quantum Dots and Pyrene-Functionalized Molecular Beacons for Detection of MicroRNAs.

1. A highly sensitive and selective signal-on strategy for microRNA quantification.

2. MoS₂ quantum dots modified with a labeled molecular beacon as a ratiometric fluorescent gene probe for FRET based detection and imaging of microRNA.

Review 3. Applications of Graphene Quantum Dots in Biomedical Sensors.

Review 4. Graphene quantum dots: synthesis, properties, and applications to the development of optical and electrochemical sensors for chemical sensing.

5. Ultrasensitive fluorescence detection of microRNA through DNA-induced assembly of carbon dots on gold nanoparticles with no signal amplification strategy.

6. Long-term continuous monitoring of microRNA in living cells using modified gold nanoprobe.

Review 7. A review on graphene-based nanocomposites for electrochemical and fluorescent biosensors.

Review 8. Emerging Biosensing Approaches for microRNA Analysis.

Review 9. Graphene and its derivatives as biomedical materials: future prospects and challenges.

10. Paper strip-embedded graphene quantum dots: a screening device with a smartphone readout.

Universal Fluorescence Biosensor Platform Based on Graphene Quantum Dots and Pyrene-Functionalized Molecular Beacons for Detection of MicroRNAs.

1. A highly sensitive and selective signal-on strategy for microRNA quantification.

2. MoS2 quantum dots modified with a labeled molecular beacon as a ratiometric fluorescent gene probe for FRET based detection and imaging of microRNA.

Review 3. Applications of Graphene Quantum Dots in Biomedical Sensors.

Review 4. Graphene quantum dots: synthesis, properties, and applications to the development of optical and electrochemical sensors for chemical sensing.

5. Ultrasensitive fluorescence detection of microRNA through DNA-induced assembly of carbon dots on gold nanoparticles with no signal amplification strategy.

6. Long-term continuous monitoring of microRNA in living cells using modified gold nanoprobe.

Review 7. A review on graphene-based nanocomposites for electrochemical and fluorescent biosensors.

Review 8. Emerging Biosensing Approaches for microRNA Analysis.

Review 9. Graphene and its derivatives as biomedical materials: future prospects and challenges.

10. Paper strip-embedded graphene quantum dots: a screening device with a smartphone readout.

2. MoS₂ quantum dots modified with a labeled molecular beacon as a ratiometric fluorescent gene probe for FRET based detection and imaging of microRNA.