Dong Xie1, Randolph Marks, Mingrui Zhang, Gening Jiang, Aminah Jatoi, Yolanda I Garces, Aaron Mansfield, Julian Molina, Ping Yang. 1. *Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China; †Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, ‡Division of Medical Oncology, and §Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Abstract
BACKGROUND: We sought to build prognostic nomograms and identify novel prognostic factors in small-cell lung cancer (SCLC) incorporating both clinical data and peripheral blood markers. METHODS: We analyzed 938 patients with SCLC (555 extensive stage SCLC [ES-SCLC] and 383 limited stage SCLC [LS-SCLC]) diagnosed between 1997 and 2012 from a single institution. We investigated the prognostic value of pretreatment neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, red cell distribution width, hemoglobin, and other clinicopathological factors. Cox proportional hazards models determined the effects of multiple factors on overall survival (OS). Two nomograms were developed to predict median survival and 6- and 12-month OS for ES-SCLC, and 1- and 2-year OS for LS-SCLC. RESULTS: In ES-SCLC, the multivariate Cox model identified neutrophil to lymphocyte ratio and red cell distribution width as significant prognostic factors for OS independent of age, Eastern Cooperative Oncology Group performance score, chest radiation, chemotherapy, liver metastases, and numbers of metastatic sites. In LS-SCLC, significant prognostic variables included platelet to lymphocyte ratio, age, smoking cessation, chest radiation, chemotherapy, surgery, and prophylactic cranial irradiation. The two nomograms show good accuracy in predicting OS, with a concordance index of 0.73 in both ES- and LS-SCLC. CONCLUSION: The two nomograms incorporating hematological markers could more accurately predict individualized survival probability of SCLC than the existing models.
BACKGROUND: We sought to build prognostic nomograms and identify novel prognostic factors in small-cell lung cancer (SCLC) incorporating both clinical data and peripheral blood markers. METHODS: We analyzed 938 patients with SCLC (555 extensive stage SCLC [ES-SCLC] and 383 limited stage SCLC [LS-SCLC]) diagnosed between 1997 and 2012 from a single institution. We investigated the prognostic value of pretreatment neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, red cell distribution width, hemoglobin, and other clinicopathological factors. Cox proportional hazards models determined the effects of multiple factors on overall survival (OS). Two nomograms were developed to predict median survival and 6- and 12-month OS for ES-SCLC, and 1- and 2-year OS for LS-SCLC. RESULTS: In ES-SCLC, the multivariate Cox model identified neutrophil to lymphocyte ratio and red cell distribution width as significant prognostic factors for OS independent of age, Eastern Cooperative Oncology Group performance score, chest radiation, chemotherapy, liver metastases, and numbers of metastatic sites. In LS-SCLC, significant prognostic variables included platelet to lymphocyte ratio, age, smoking cessation, chest radiation, chemotherapy, surgery, and prophylactic cranial irradiation. The two nomograms show good accuracy in predicting OS, with a concordance index of 0.73 in both ES- and LS-SCLC. CONCLUSION: The two nomograms incorporating hematological markers could more accurately predict individualized survival probability of SCLC than the existing models.
Authors: Paul A Bunn; John D Minna; Alexander Augustyn; Adi F Gazdar; Youcef Ouadah; Mark A Krasnow; Anton Berns; Elisabeth Brambilla; Natasha Rekhtman; Pierre P Massion; Matthew Niederst; Martin Peifer; Jun Yokota; Ramaswamy Govindan; John T Poirier; Lauren A Byers; Murry W Wynes; David G McFadden; David MacPherson; Christine L Hann; Anna F Farago; Caroline Dive; Beverly A Teicher; Craig D Peacock; Jane E Johnson; Melanie H Cobb; Hans-Guido Wendel; David Spigel; Julien Sage; Ping Yang; M Catherine Pietanza; Lee M Krug; John Heymach; Peter Ujhazy; Caicun Zhou; Koichi Goto; Afshin Dowlati; Camilla Laulund Christensen; Keunchil Park; Lawrence H Einhorn; Martin J Edelman; Giuseppe Giaccone; David E Gerber; Ravi Salgia; Taofeek Owonikoko; Shakun Malik; Niki Karachaliou; David R Gandara; Ben J Slotman; Fiona Blackhall; Glenwood Goss; Roman Thomas; Charles M Rudin; Fred R Hirsch Journal: J Thorac Oncol Date: 2016-01-30 Impact factor: 15.609
Authors: Ryoko Suzuki; Steven H Lin; Xiong Wei; Pamela K Allen; James W Welsh; Lauren A Byers; Ritsuko Komaki Journal: Radiother Oncol Date: 2018-02-02 Impact factor: 6.280