Literature DB >> 26200058

Neuroinflammation in the pathophysiology of Parkinson's disease and therapeutic evidence of anti-inflammatory drugs.

Taysa Bervian Bassani1, Maria A B F Vital2, Laryssa K Rauh1.   

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disease affecting approximately 1.6% of the population over 60 years old. The cardinal motor symptoms are the result of progressive degeneration of substantia nigra pars compacta dopaminergic neurons which are involved in the fine motor control. Currently, there is no cure for this pathology and the cause of the neurodegeneration remains unknown. Several studies suggest the involvement of neuroinflammation in the pathophysiology of PD as well as a protective effect of anti-inflammatory drugs both in animal models and epidemiological studies, although there are controversial reports. In this review, we address evidences of involvement of inflammatory process and possible therapeutic usefulness of anti-inflammatory drugs in PD.

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Year:  2015        PMID： 26200058     DOI： 10.1590/0004-282X20150057

Source DB:  PubMed          Journal:  Arq Neuropsiquiatr        ISSN： 0004-282X            Impact factor:   1.420


  22 in total

1.  Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease.

Authors:  Xiaojuan Han; Sifan Sun; Yiming Sun; Qiqi Song; Jialei Zhu; Nanshan Song; Miaomiao Chen; Ting Sun; Meiling Xia; Jianhua Ding; Ming Lu; Honghong Yao; Gang Hu
Journal:  Autophagy       Date:  2019-04-09       Impact factor: 16.016

2.  Neuroinflammation Induces Neurodegeneration.

Authors:  D Kempuraj; R Thangavel; P A Natteru; G P Selvakumar; D Saeed; H Zahoor; S Zaheer; S S Iyer; A Zaheer
Journal:  J Neurol Neurosurg Spine       Date:  2016-11-18

3.  A Systematic Review of MicroRNA Expression as Biomarker of Late-Onset Alzheimer's Disease.

Authors:  Soraya Herrera-Espejo; Borja Santos-Zorrozua; Paula Álvarez-González; Elixabet Lopez-Lopez; África Garcia-Orad
Journal:  Mol Neurobiol       Date:  2019-06-25       Impact factor: 5.590

4.  IGF-1 Gene Transfer Modifies Inflammatory Environment and Gene Expression in the Caudate-Putamen of Aged Female Rat Brain.

Authors:  Claudia Beatriz Hereñú; María José Bellini; Eugenia Falomir-Lockhart; Franco Juan Cruz Dolcetti; Macarena Lorena Herrera; Jerónimo Pennini; María Florencia Zappa Villar; Gabriela Salinas; Enrique Portiansky; Björn Spittau; Ezequiel Lacunza
Journal:  Mol Neurobiol       Date:  2022-03-19       Impact factor: 5.590

Review 5.  Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder.

Authors:  Reza Rahimian; Claudia Belliveau; Rebecca Chen; Naguib Mechawar
Journal:  Front Psychiatry       Date:  2022-06-16       Impact factor: 5.435

6.  Glia Maturation Factor and Mast Cell-Dependent Expression of Inflammatory Mediators and Proteinase Activated Receptor-2 in Neuroinflammation.

Authors:  Duraisamy Kempuraj; Govindhasamy Pushpavathi Selvakumar; Ramasamy Thangavel; Mohammad Ejaz Ahmed; Smita Zaheer; Keerthana Kuppamma Kumar; Anudeep Yelam; Harleen Kaur; Iuliia Dubova; Sudhanshu P Raikwar; Shankar S Iyer; Asgar Zaheer
Journal:  J Alzheimers Dis       Date:  2018       Impact factor: 4.472

7.  Pramipexole attenuates 6-OHDA-induced Parkinson's disease by mediating the Nurr1/NF-κB pathway.

Authors:  Hua Gao; Dan Wang; Yu-Ling Wang; Jie-Ping Mao; Sen Jiang; Xin-Ling Yang
Journal:  Mol Biol Rep       Date:  2021-04-23       Impact factor: 2.316

8.  MicroRNA-124 regulates the expression of MEKK3 in the inflammatory pathogenesis of Parkinson's disease.

Authors:  Longping Yao; Yongyi Ye; Hengxu Mao; Fengfei Lu; Xiaozheng He; Guohui Lu; Shizhong Zhang
Journal:  J Neuroinflammation       Date:  2018-01-12       Impact factor: 8.322

9.  Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases.

Authors:  Ana López; Francisco Ortiz; Carolina Doerrier; Carmen Venegas; Marisol Fernández-Ortiz; Paula Aranda; María E Díaz-Casado; Beatriz Fernández-Gil; Eliana Barriocanal-Casado; Germaine Escames; Luis C López; Darío Acuña-Castroviejo
Journal:  PLoS One       Date:  2017-08-11       Impact factor: 3.240

10.  Contribution of Pro-inflammatory Cytokine Signaling within Midbrain Periaqueductal Gray to Pain Sensitivity in Parkinson's Disease via GABAergic Pathway.

Authors:  Xianbo Zhuang; Yanxiu Chen; Xianpeng Zhuang; Tuanzhi Chen; Tao Xing; Weifei Wang; Xiafeng Yang
Journal:  Front Neurol       Date:  2016-07-25       Impact factor: 4.003
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