Literature DB >> 26200009

Escaping Negative Selection: ILC You in the Gut.

Adam M Farkas1, Ivaylo I Ivanov2.   

Abstract

How commensal-specific T cells are controlled in the periphery is poorly understood. In a recent issue of Science, Hepworth et al. (2015) show that ILC3s induce apoptosis of microbiota-specific CD4 T cells in a form of extrathymic negative selection.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 26200009      PMCID： PMC4767161          DOI： 10.1016/j.immuni.2015.07.006

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  10 in total

1.  Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria.

Authors:  Andrew J Macpherson; Therese Uhr
Journal:  Science       Date:  2004-03-12       Impact factor: 47.728

2.  Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation.

Authors:  Yoshiyuki Goto; Casandra Panea; Gaku Nakato; Anna Cebula; Carolyn Lee; Marta Galan Diez; Terri M Laufer; Leszek Ignatowicz; Ivaylo I Ivanov
Journal:  Immunity       Date:  2014-03-27       Impact factor: 31.745

3.  Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells.

Authors:  Matthew R Hepworth; Thomas C Fung; Samuel H Masur; Judith R Kelsen; Fiona M McConnell; Juan Dubrot; David R Withers; Stephanie Hugues; Michael A Farrar; Walter Reith; Gérard Eberl; Robert N Baldassano; Terri M Laufer; Charles O Elson; Gregory F Sonnenberg
Journal:  Science       Date:  2015-04-23       Impact factor: 47.728

4.  A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota.

Authors:  Yingzi Cong; Ting Feng; Kohtaro Fujihashi; Trenton R Schoeb; Charles O Elson
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-04       Impact factor: 11.205

5.  Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses.

Authors:  Siegfried Hapfelmeier; Melissa A E Lawson; Emma Slack; Jorum K Kirundi; Maaike Stoel; Mathias Heikenwalder; Julia Cahenzli; Yuliya Velykoredko; Maria L Balmer; Kathrin Endt; Markus B Geuking; Roy Curtiss; Kathy D McCoy; Andrew J Macpherson
Journal:  Science       Date:  2010-06-25       Impact factor: 47.728

Review 6.  Immune adaptations that maintain homeostasis with the intestinal microbiota.

Authors:  Lora V Hooper; Andrew J Macpherson
Journal:  Nat Rev Immunol       Date:  2010-03       Impact factor: 53.106

Review 7.  Contextual functions of antigen-presenting cells in the gastrointestinal tract.

Authors:  John R Grainger; Michael H Askenase; Fanny Guimont-Desrochers; Denise Morais da Fonseca; Yasmine Belkaid
Journal:  Immunol Rev       Date:  2014-05       Impact factor: 12.988

8.  Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis.

Authors:  Arthur Mortha; Aleksey Chudnovskiy; Daigo Hashimoto; Milena Bogunovic; Sean P Spencer; Yasmine Belkaid; Miriam Merad
Journal:  Science       Date:  2014-03-13       Impact factor: 47.728

9.  CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes.

Authors:  Emma C Mackley; Stephanie Houston; Clare L Marriott; Emily E Halford; Beth Lucas; Vuk Cerovic; Kara J Filbey; Rick M Maizels; Matthew R Hepworth; Gregory F Sonnenberg; Simon Milling; David R Withers
Journal:  Nat Commun       Date:  2015-01-09       Impact factor: 14.919

10.  Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria.

Authors:  Matthew R Hepworth; Laurel A Monticelli; Thomas C Fung; Carly G K Ziegler; Stephanie Grunberg; Rohini Sinha; Adriana R Mantegazza; Hak-Ling Ma; Alison Crawford; Jill M Angelosanto; E John Wherry; Pandelakis A Koni; Frederic D Bushman; Charles O Elson; Gérard Eberl; David Artis; Gregory F Sonnenberg
Journal:  Nature       Date:  2013-05-22       Impact factor: 49.962
  10 in total
  1 in total

1.  Oxygen regulates ILC3 antigen presentation potential and pregnancy-related hormone actions.

Authors:  Rebekka Einenkel; Jens Ehrhardt; Marek Zygmunt; Damián Oscar Muzzio
Journal:  Reprod Biol Endocrinol       Date:  2022-07-29       Impact factor: 4.982
  1 in total

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