Literature DB >> 26199895

Lovenox Induced Tissue Necrosis, a Case Report and Literature Review.

Abdelfatah Abou Issa1, Richard Simman2.   

Abstract

Lovenox is a trade name for Enoxaparin. It is a low molecular weight heparin (LMWH) and has other trade names like Clexane and Xaparin. It is an anticoagulant used to prevent and treat venous thromboembolism events (VTE) like deep vein thrombosis or pulmonary embolism, and is given as a subcutaneous injection. General speaking, the most common skin reactions as a result of enoxaparin use are: urticarial, ecchymosis, and even skin necrosis due to vasculitis. These side effects are usually located at the injection site. New studies have pointed out the side effect that could occur a distance from the site of Lovenox injection. In our case extensive skin and subcutaneous tissue necrosis developed at the abdominal wall injection site.

Entities:  

Keywords:  DVT prophylaxis; Injection site; Lovenox; Low molecular weight heparin; Skin necrosis

Year:  2015        PMID: 26199895      PMCID: PMC4495755          DOI: 10.1016/j.jccw.2015.03.001

Source DB:  PubMed          Journal:  J Am Coll Clin Wound Spec        ISSN: 2213-5103


  13 in total

1.  Low-molecular-weight heparin-induced skin necrosis: a potential association with pre-existent hypercoagulable states.

Authors:  Agustí Toll; Fernando Gallardo; M Eugenia Abella; Jaume Fontcuberta; Carlos Barranco; Ramon M Pujol
Journal:  Int J Dermatol       Date:  2005-11       Impact factor: 2.736

2.  Pharmacokinetic analysis of enoxaparin in a term neonate and review of literature.

Authors:  Marion K Mateos; Felicity A Wright; Richard J Cohn
Journal:  Thromb Res       Date:  2013-08-29       Impact factor: 3.944

Review 3.  Heparin-induced thrombocytopenia: a review.

Authors:  Bruno Girolami; Antonio Girolami
Journal:  Semin Thromb Hemost       Date:  2006-11       Impact factor: 4.180

4.  Skin necrosis induced by generic enoxaparin.

Authors:  Ayca Gucalp; Rekha Parameswaran; Mario Lacouture; Ghassan Abou-Alfa; Gerald Soff
Journal:  Am J Hematol       Date:  2013-02-28       Impact factor: 10.047

5.  Drug-induced dilemma: angiokeratomas and decreased renal function.

Authors:  Stefan Schliep; Franklin Kiesewetter; Miklos Simon; Clemens Grupp; Lucie Heinzerling
Journal:  Am J Med       Date:  2014-04-13       Impact factor: 4.965

6.  [Enoxaparin-induced cutaneous necrosis localized on insulin lipodystrophies].

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Journal:  Ann Dermatol Venereol       Date:  1997       Impact factor: 0.777

Review 7.  Hypersensitivity reactions to anticoagulant drugs: diagnosis and management options.

Authors:  A J Bircher; T Harr; L Hohenstein; D A Tsakiris
Journal:  Allergy       Date:  2006-12       Impact factor: 13.146

8.  An assessment of published pediatric dosage guidelines for enoxaparin: a retrospective review.

Authors:  Sharon H Ho; John K Wu; Donald P Hamilton; David B Dix; Louis D Wadsworth
Journal:  J Pediatr Hematol Oncol       Date:  2004-09       Impact factor: 1.289

Review 9.  The pharmacoeconomics of deep vein thrombosis treatment.

Authors:  Andrew F Shorr
Journal:  Am J Med       Date:  2007-10       Impact factor: 4.965

10.  Low molecular weight heparin-induced skin necrosis: a case report.

Authors:  Anastasios Katsourakis; George Noussios; George Kapoutsis; Efthimios Chatzitheoklitos
Journal:  Case Rep Med       Date:  2011-05-30
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  3 in total

1.  Subcutaneous Toxicity of Agmatine in Rats.

Authors:  Tayfun Uzbay; Fatma Duygu Kaya Yertutanol; Ahmet Midi; Burcu Çevreli
Journal:  Turk J Pharm Sci       Date:  2017-08-15

2.  Enoxaparin-Induced Skin Necrosis.

Authors:  James Coelho; David Izadi; Sameer Gujral
Journal:  Eplasty       Date:  2016-09-21

3.  Enoxaparin-induced skin necrosis at injection site after total knee arthroplasty.

Authors:  Max Haffner; Nasser Heyrani; John P Meehan; Mauro Giordani
Journal:  Arthroplast Today       Date:  2017-10-21
  3 in total

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