Literature DB >> 26199885

Treatment of Burn Wound Infection Using Ultraviolet Light: A Case Report.

Numra Abdul Aleem1, Moaz Aslam1, Mohammad Faizan Zahid1, Arshalooz Jamila Rahman2, Fazl Ur Rehman3.   

Abstract

A 9 year old girl presented to us with complaints of fever and pain in burn wounds with deteriorating health for one month. According to Lund and Broder's chart, burns spanned the posterior trunk (13%), right arm (1.5%), left arm (1.5%), and buttocks (2.5%). The wounds showed improper healing. She had previously underwent split-thickness skin grafting, using skin harvests from thighs and antimicrobial therapy with vancomycin, fluconazole and colomycin with limited clinical improvement. Analgesia was administered. Blood cultures and tissue cultures from the burns indicated polymicrobial wound infection and sepsis, including methicillin resistant Staphylococcus aureus, Klebsiella pneumoniae and Pseudomonas aeruginosa. Despite broad-spectrum antibiotics, fever persisted and condition deteriorated. Antifungals were also administered with no clinical improvement. Eventually another split-thickness skin grafting was done to provide fresh grafts. In due course, ultraviolet light exposure, of wavelength 32-40 nm/W/cm(2), was considered for treatment. In prone position, the wounds were exposed to ultraviolet phototherapy 6-8 h daily for 8 days. Eventually, wound healing and sepsis improved. Antibiotics were optimized and high protein diet was started. Eventually the wounds showed fresh margins and visible signs of healing. With remarkable clinical improvement and no further fever spikes, the patient was eventually discharged. She was advised to shower regularly, apply bandages with acetic acid. On her last outpatient follow up, 2 weeks after discharge, she was doing well, with no complaints of pain or fever. Examination of burns showed clean wounds, with clear margins and good graft uptake. She did not require any further grafting or surgical procedures thereafter.

Entities:  

Keywords:  Antibiotics; Burns; Sepsis; Ultraviolet light; Wound infection

Year:  2014        PMID: 26199885      PMCID: PMC4495744          DOI: 10.1016/j.jccw.2014.07.002

Source DB:  PubMed          Journal:  J Am Coll Clin Wound Spec        ISSN: 2213-5103


  11 in total

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Authors:  H-O Rennekampff; M N Busche; K Knobloch; M Tenenhaus
Journal:  Med Hypotheses       Date:  2010-05-05       Impact factor: 1.538

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Authors:  T A Conner-Kerr; P K Sullivan; J Gaillard; M E Franklin; R M Jones
Journal:  Ostomy Wound Manage       Date:  1998-10       Impact factor: 2.629

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Authors:  G J Taylor; G C Bannister; J P Leeming
Journal:  J Hosp Infect       Date:  1995-06       Impact factor: 3.926

4.  Ultraviolet-C light for treatment of Candida albicans burn infection in mice.

Authors:  Tianhong Dai; Gitika B Kharkwal; Jie Zhao; Tyler G St Denis; Qiuhe Wu; Yumin Xia; Liyi Huang; Sulbha K Sharma; Christophe d'Enfert; Michael R Hamblin
Journal:  Photochem Photobiol       Date:  2011-02-10       Impact factor: 3.421

5.  Comparison of ultrasound/ultraviolet-C and laser for treatment of pressure ulcers in patients with spinal cord injury.

Authors:  E L Nussbaum; I Biemann; B Mustard
Journal:  Phys Ther       Date:  1994-09

6.  Ultraviolet light C in the treatment of chronic wounds with MRSA: a case study.

Authors:  Thao P Thai; Pamela E Houghton; Karen E Campbell; M Gail Woodbury
Journal:  Ostomy Wound Manage       Date:  2002-11       Impact factor: 2.629

Review 7.  Ultraviolet C irradiation: an alternative antimicrobial approach to localized infections?

Authors:  Tianhong Dai; Mark S Vrahas; Clinton K Murray; Michael R Hamblin
Journal:  Expert Rev Anti Infect Ther       Date:  2012-02       Impact factor: 5.091

8.  Effect of ultraviolet light C on bacterial colonization in chronic wounds.

Authors:  Thao P Thai; David H Keast; Karen E Campbell; M Gail Woodbury; Pamela E Houghton
Journal:  Ostomy Wound Manage       Date:  2005-10       Impact factor: 2.629

9.  Ultraviolet C light for Acinetobacter baumannii wound infections in mice: potential use for battlefield wound decontamination?

Authors:  Tianhong Dai; Clinton K Murray; Mark S Vrahas; David G Baer; George P Tegos; Michael R Hamblin
Journal:  J Trauma Acute Care Surg       Date:  2012-09       Impact factor: 3.313

10.  The effect of ultraviolet rays on the prevention of exit-site infections.

Authors:  A Shimomura; D Tahara; M Tominaga; S Uchigiri; Y Yamaguchi; H Ishioka; A Nakahata
Journal:  Adv Perit Dial       Date:  1995
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  3 in total

Review 1.  Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing.

Authors:  Mirza Ali Mofazzal Jahromi; Parham Sahandi Zangabad; Seyed Masoud Moosavi Basri; Keyvan Sahandi Zangabad; Ameneh Ghamarypour; Amir R Aref; Mahdi Karimi; Michael R Hamblin
Journal:  Adv Drug Deliv Rev       Date:  2017-08-04       Impact factor: 15.470

Review 2.  [Beyond antibiotic therapy - Future antiinfective strategies - Update 2017].

Authors:  D Vogt; S Sperling; T Tkhilaishvili; A Trampuz; J-P Pirnay; C Willy
Journal:  Unfallchirurg       Date:  2017-07       Impact factor: 1.000

3.  Guidelines for burn rehabilitation in China.

Authors:  Ying Cen; Jiake Chai; Huade Chen; Jian Chen; Guanghua Guo; Chunmao Han; Dahai Hu; Jingning Huan; Xiaoyuan Huang; Chiyu Jia; Cecilia Wp Li-Tsang; Jianan Li; Zongyu Li; Qun Liu; Yi Liu; Gaoxing Luo; Guozhong Lv; Xihua Niu; Daizhi Peng; Yizhi Peng; Hongyan Qi; Shunzhen Qi; Zhiyong Sheng; Dan Tang; Yibing Wang; Jun Wu; Zhaofan Xia; Weiguo Xie; Hongming Yang; Xianfeng Yi; Lehua Yu; Guoan Zhang
Journal:  Burns Trauma       Date:  2015-10-21
  3 in total

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