Saeed Shoja Shafti1, Hamid Kaviani2. 1. Associate Professor of Psychiatry, University of Social Welfare and Rehabilitation Sciences (USWR), Razi Psychiatric Hospital, PO Box 18735-569, Tehran, Iran. 2. University of Azad, Tehran, Iran.
Abstract
OBJECTIVES: Current evidence supports the use of various second-generation antipsychotics for pharmacotherapy of schizophrenia. While in a systematic review, generally no difference in efficacy was found between atypical antipsychotics, other studies have found quetiapine less effective than aripiprazole. This article reviews the efficacy and tolerability of aripiprazole versus quetiapine in the context of recommended management strategies for schizophrenia. METHOD: Fifty female inpatients, meeting the diagnosis of schizophrenia, were randomly entered into two groups (n = 25 in each group) to participate in a 12-week, double-blind study for random assignment to quetiapine or aripiprazole. The primary outcome measures were Scale for Assessment of Positive Symptoms and Scale for Assessment of Negative Symptoms. The schedule for Assessment of Insight (SAI), Clinical Global Impressions Severity Scale (CGI-S) and the Simpson Angus Scale (SAS) were also used as secondary measures. RESULTS: Both quetiapine and aripiprazole showed significant effectiveness in the improvement of positive symptoms. The effectiveness for negative symptoms was also noteworthy with both drugs, although not to a significant level during this study. In addition, significant improvement was found on assessment with CGI-S and SAI for quetiapine and aripiprazole. SAS did not show any important increment in extrapyramidal side effects at the end of the examination. CONCLUSION: According to the findings, quetiapine and aripiprazole had similar effectiveness and tolerability with respect to management of schizophrenia.
RCT Entities:
OBJECTIVES: Current evidence supports the use of various second-generation antipsychotics for pharmacotherapy of schizophrenia. While in a systematic review, generally no difference in efficacy was found between atypical antipsychotics, other studies have found quetiapine less effective than aripiprazole. This article reviews the efficacy and tolerability of aripiprazole versus quetiapine in the context of recommended management strategies for schizophrenia. METHOD: Fifty female inpatients, meeting the diagnosis of schizophrenia, were randomly entered into two groups (n = 25 in each group) to participate in a 12-week, double-blind study for random assignment to quetiapine or aripiprazole. The primary outcome measures were Scale for Assessment of Positive Symptoms and Scale for Assessment of Negative Symptoms. The schedule for Assessment of Insight (SAI), Clinical Global Impressions Severity Scale (CGI-S) and the Simpson Angus Scale (SAS) were also used as secondary measures. RESULTS: Both quetiapine and aripiprazole showed significant effectiveness in the improvement of positive symptoms. The effectiveness for negative symptoms was also noteworthy with both drugs, although not to a significant level during this study. In addition, significant improvement was found on assessment with CGI-S and SAI for quetiapine and aripiprazole. SAS did not show any important increment in extrapyramidal side effects at the end of the examination. CONCLUSION: According to the findings, quetiapine and aripiprazole had similar effectiveness and tolerability with respect to management of schizophrenia.
Authors: Benedicto Crespo-Facorro; Rocío Pérez-Iglesias; Ignacio Mata; Victor Ortiz-Garcia de la Foz; Obdulia Martínez-Garcia; Elsa M Valdizan; José L Vazquez-Barquero Journal: J Clin Psychopharmacol Date: 2013-04 Impact factor: 3.153
Authors: Marian S McDonagh; Tracy Dana; Shelley Selph; Emily B Devine; Amy Cantor; Christina Bougatsos; Ian Blazina; Sara Grusing; Rongwei Fu; Daniel W Haupt Journal: Psychiatr Res Clin Pract Date: 2020-10-16