| Literature DB >> 26199356 |
Naila Makhani1, Brenda Banwell2, Raymond Tellier3, Carmen Yea4, Suzanne McGovern4, Julia O'Mahony5, Jean M Ahorro6, Douglas Arnold7, A Dessa Sadovnick8, Ruth A Marrie9, Amit Bar-Or7.
Abstract
Epstein-Barr virus (EBV) infection is associated with increased multiple sclerosis (MS) risk. Recently, cytomegalovirus (CMV) infection has been proposed as a protective factor against MS development. We determined EBV, herpes simplex virus, varicella-zoster virus and CMV seroprevalence in 247 prospectively followed children with acquired demyelinating syndromes (ADS). Remote EBV infection was more common in children with MS than those with monophasic ADS while CMV infection was more common in children with monophasic ADS. Children displaying evidence of remote EBV without CMV infection were at highest risk of subsequent MS diagnosis. Viral infection repertoire detected at ADS provides important prognostic information.Entities:
Keywords: Epstein–Barr virus; Multiple sclerosis; cytomegalovirus; pediatric; risk factors
Mesh：
Substances：
Year: 2015 PMID： 26199356 DOI： 10.1177/1352458515595876
Source DB: PubMed Journal: Mult Scler ISSN： 1352-4585 Impact factor: 6.312