Literature DB >> 26198936

Chronic ethanol exposure combined with high fat diet up-regulates P2X7 receptors that parallels neuroinflammation and neuronal loss in C57BL/6J mice.

Liana Asatryan1, Sheraz Khoja2, Kathleen E Rodgers3, Ronald L Alkana2, Hidekazu Tsukamoto4, Daryl L Davies3.   

Abstract

The present investigation tested the role of ATP-activated P2X7 receptors (P2X7Rs) in alcohol-induced brain damage using a model that combines intragastric (iG) ethanol feeding and high fat diet in C57BL/6J mice (Hybrid). The Hybrid paradigm caused increased levels of pro-inflammatory markers, changes in microglia and astrocytes, reduced levels of neuronal marker NeuN and increased P2X7R expression in ethanol-sensitive brain regions. Observed changes in P2X7R and NeuN expression were more pronounced in Hybrid paradigm with inclusion of additional weekly binges. In addition, high fat diet during Hybrid exposure aggravated the increase in P2X7R expression and activation of glial cells.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Astrocytes; High fat diet; Intragastric ethanol feeding; Microglia; Neuroinflammation and neuronal loss; Pro-inflammatory cytokines; Purinergic P2X7 receptors

Mesh：

Substances：

Year:  2015        PMID： 26198936      PMCID： PMC4512299          DOI： 10.1016/j.jneuroim.2015.06.007

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  56 in total

1.  P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease.

Authors:  Lav K Parvathenani; Svetlana Tertyshnikova; Corinne R Greco; Susan B Roberts; Barbara Robertson; Rand Posmantur
Journal:  J Biol Chem       Date:  2003-01-27       Impact factor: 5.157

2.  Urokinase-type plasminogen activator induces BV-2 microglial cell migration through activation of matrix metalloproteinase-9.

Authors:  Sun Mi Shin; Kyu Suk Cho; Min Sik Choi; Sung Hoon Lee; Seol-Heui Han; Young-Sun Kang; Hee Jin Kim; Jae Hoon Cheong; Chan Young Shin; Kwang Ho Ko
Journal:  Neurochem Res       Date:  2010-02-23       Impact factor: 3.996

3.  ALS: focus on purinergic signalling.

Authors:  Cinzia Volonté; Savina Apolloni; Maria Teresa Carrì; Nadia D'Ambrosi
Journal:  Pharmacol Ther       Date:  2011-06-16       Impact factor: 12.310

Review 4.  Acute and chronic effects of ethanol on learning-related synaptic plasticity.

Authors:  Charles F Zorumski; Steven Mennerick; Yukitoshi Izumi
Journal:  Alcohol       Date:  2013-12-16       Impact factor: 2.405

Review 5.  Alcoholism and inflammation: neuroimmunology of behavioral and mood disorders.

Authors:  Keith W Kelley; Robert Dantzer
Journal:  Brain Behav Immun       Date:  2010-12-28       Impact factor: 7.217

6.  Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice.

Authors:  Raul Lazaro; Raymond Wu; Sunyoung Lee; Nian-Ling Zhu; Chia-Lin Chen; Samuel W French; Jun Xu; Keigo Machida; Hidekazu Tsukamoto
Journal:  Hepatology       Date:  2014-11-25       Impact factor: 17.425

7.  Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK.

Authors:  Jun Xu; Keane K Y Lai; Alla Verlinsky; Aurelia Lugea; Samuel W French; Marcus P Cooper; Cheng Ji; Hidekazu Tsukamoto
Journal:  J Hepatol       Date:  2011-01-21       Impact factor: 25.083

8.  Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity.

Authors:  Marciane Milanski; Giovanna Degasperi; Andressa Coope; Joseane Morari; Raphael Denis; Dennys E Cintra; Daniela M L Tsukumo; Gabriel Anhe; Maria E Amaral; Hilton K Takahashi; Rui Curi; Helena C Oliveira; José B C Carvalheira; Silvana Bordin; Mário J Saad; Lício A Velloso
Journal:  J Neurosci       Date:  2009-01-14       Impact factor: 6.167

Review 9.  Alcoholism: protein expression profiles in a human hippocampal model.

Authors:  Haruka Matsumoto; Izuru Matsumoto
Journal:  Expert Rev Proteomics       Date:  2008-04       Impact factor: 3.940

10.  Resveratrol attenuates obesity-associated peripheral and central inflammation and improves memory deficit in mice fed a high-fat diet.

Authors:  Byeong Tak Jeon; Eun Ae Jeong; Hyun Joo Shin; Younghyurk Lee; Dong Hoon Lee; Hyun Joon Kim; Sang Soo Kang; Gyeong Jae Cho; Wan Sung Choi; Gu Seob Roh
Journal:  Diabetes       Date:  2012-02-23       Impact factor: 9.461
View more
  6 in total

1.  Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice.

Authors:  Jun Xu; Hsiao-Yen Ma; Xiao Liu; Sara Rosenthal; Jacopo Baglieri; Ryan McCubbin; Mengxi Sun; Yukinori Koyama; Cedric G Geoffroy; Kaoru Saijo; Linshan Shang; Takahiro Nishio; Igor Maricic; Max Kreifeldt; Praveen Kusumanchi; Amanda Roberts; Binhai Zheng; Vipin Kumar; Karsten Zengler; Donald P Pizzo; Mojgan Hosseini; Candice Contet; Christopher K Glass; Suthat Liangpunsakul; Hidekazu Tsukamoto; Bin Gao; Michael Karin; David A Brenner; George F Koob; Tatiana Kisseleva
Journal:  JCI Insight       Date:  2020-02-13

2.  P2X7 Receptor Antagonist A804598 Inhibits Inflammation in Brain and Liver in C57BL/6J Mice Exposed to Chronic Ethanol and High Fat Diet.

Authors:  Daniel Freire; Rachel E Reyes; Ared Baghram; Daryl L Davies; Liana Asatryan
Journal:  J Neuroimmune Pharmacol       Date:  2018-10-23       Impact factor: 4.147

3.  Inhibition of the Inflammasome Signaling Cascade Reduces Alcohol Consumption in Female But Not Male Mice.

Authors:  Patrick P Lowe; Yeonhee Cho; David Tornai; Sahin Coban; Donna Catalano; Gyongyi Szabo
Journal:  Alcohol Clin Exp Res       Date:  2020-01-09       Impact factor: 3.455

Review 4.  Astroglial correlates of neuropsychiatric disease: From astrocytopathy to astrogliosis.

Authors:  Ronald Kim; Kati L Healey; Marian T Sepulveda-Orengo; Kathryn J Reissner
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2017-10-06       Impact factor: 5.067

5.  Pairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice.

Authors:  Macarena González-Portilla; Sandra Montagud-Romero; Francisco Navarrete; Ani Gasparyan; Jorge Manzanares; José Miñarro; Marta Rodríguez-Arias
Journal:  Int J Mol Sci       Date:  2021-05-17       Impact factor: 5.923

Review 6.  Inflammatory Biomarkers in Addictive Disorders.

Authors:  Alvaro Morcuende; Francisco Navarrete; Elena Nieto; Jorge Manzanares; Teresa Femenía
Journal:  Biomolecules       Date:  2021-12-03
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.