| Literature DB >> 26198931 |
Fernanda Pedrotti Moreira1, Taiane de Azevedo Cardoso1, Thaíse Campos Mondin1, Luciano Dias de Mattos Souza1, Ricardo Silva1, Karen Jansen1, Jean Pierre Oses1, Carolina David Wiener2.
Abstract
Major depressive disorder (MDD) is a debilitating disorder and its pathophysiology is associated with deregulation of the immune system. We investigated the changes in circulating levels of proinflammatory cytokines (specifically IL-6 and TNF-α) measured by the ELISA kit in two psychotherapeutic interventions for MDD: Narrative Cognitive Therapy (NCT) and Cognitive Behavioral Therapy (CBT). This is a randomized clinical trial including 97 individuals (18 to 29years-old) with MDD. In CBT there was a significant difference in serum levels of IL-6 and TNF-α, therefore indicating that CBT was more effective than NCT on serum levels proinflammatory cytokines.Entities:
Keywords: Cognitive Behavioral Therapy (CBT); Depression; Interleukin-6 (IL-6); Proinflammatory cytokines; Tumor necrosis factor alpha (TNF-α)
Mesh:
Substances:
Year: 2015 PMID: 26198931 DOI: 10.1016/j.jneuroim.2015.06.004
Source DB: PubMed Journal: J Neuroimmunol ISSN: 0165-5728 Impact factor: 3.478