Literature DB >> 26198925

Promiscuity of autoimmune responses to MBP after stroke.

Dannielle Zierath1, Allison Kunze1, Leia Fecteau1, Kyra Becker2.   

Abstract

In this study we examined Th1 and Th17 immune responses to rat myelin basic protein (MBP), bovine MBP, human MBP, MBP 68-86, MBP 63-81 and ovalbumin in Lewis rats to determine which MBP antigen is recognized following ischemic brain injury. Responses were compared to animals immunized to rat MBP. Data show that immune responses following immunization with rat MBP are promiscuous with cross reaction to MBP from other species. After stroke, few animals develop Th1 or Th17 responses to MBP, but when those responses occur, especially Th1 responses to rat MBP in the brain, they are predictive of worse stroke outcome.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Immune response; MBP; Stroke; Th1; Th17

Mesh：

Substances：

Year:  2015        PMID： 26198925      PMCID： PMC4511851          DOI： 10.1016/j.jneuroim.2015.05.024

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  27 in total

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2.  Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells.

Authors:  Ingunn M Stromnes; Lauren M Cerretti; Denny Liggitt; Robert A Harris; Joan M Goverman
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3.  Does the frequency and avidity spectrum of the neuroantigen-specific T cells in the blood mirror the autoimmune process in the central nervous system of mice undergoing experimental allergic encephalomyelitis?

Authors:  Harald H Hofstetter; Oleg S Targoni; Alexey Y Karulin; Thomas G Forsthuber; Magdalena Tary-Lehmann; Paul V Lehmann
Journal:  J Immunol       Date:  2005-04-15       Impact factor: 5.422

4.  Interstrain variability of autoimmune encephalomyelitis in rats: multiple encephalitogenic myelin basic protein epitopes for DA rats.

Authors:  J A Stepaniak; N A Wolf; D Sun; R H Swanborg
Journal:  J Neuroimmunol       Date:  1997-09       Impact factor: 3.478

5.  Stroke preceding autoimmune encephalitis with neuronal potassium channel antibody.

Authors:  Patricia Simal; Ana Maria Garcia-García; Carmen Serna-Candel; Jose Antonio Egido
Journal:  BMJ Case Rep       Date:  2012-05-08

6.  Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE.

Authors:  Marloes van Zwam; Ruth Huizinga; Marie-José Melief; Annet F Wierenga-Wolf; Marjan van Meurs; Jane S Voerman; Knut P H Biber; Hendrikus W G M Boddeke; Uta E Höpken; Christian Meisel; Andreas Meisel; Ingo Bechmann; Rogier Q Hintzen; Bert A 't Hart; Sandra Amor; Jon D Laman; Leonie A Boven
Journal:  J Mol Med (Berl)       Date:  2008-12-03       Impact factor: 4.599

7.  Long term immunologic consequences of experimental stroke and mucosal tolerance.

Authors:  J Michael Gee; Dannielle Zierath; Jessica Hadwin; Anna Savos; Angela Kalil; Matthew Thullbery; Kyra J Becker
Journal:  Exp Transl Stroke Med       Date:  2009-10-21

8.  Blood test detecting autoantibodies to N-methyl-D-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke.

Authors:  Svetlana A Dambinova; Guerman A Khounteev; Galina A Izykenova; Igor G Zavolokov; Anna Y Ilyukhina; Alexander A Skoromets
Journal:  Clin Chem       Date:  2003-10       Impact factor: 8.327

9.  Experimental autoimmune encephalomyelitis in the rat.

Authors:  Mark Mannie; Robert H Swanborg; Jolie A Stepaniak
Journal:  Curr Protoc Immunol       Date:  2009-04

10.  Reversible middle cerebral artery occlusion without craniectomy in rats.

Authors:  E Z Longa; P R Weinstein; S Carlson; R Cummins
Journal:  Stroke       Date:  1989-01       Impact factor: 7.914
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  10 in total

1.  Silencing of microRNA-494 inhibits the neurotoxic Th1 shift via regulating HDAC2-STAT4 cascade in ischaemic stroke.

Authors:  Haiping Zhao; Guangwen Li; Rongliang Wang; Zhen Tao; Qingfeng Ma; Sijia Zhang; Ziping Han; Feng Yan; Fangfang Li; Ping Liu; Shubei Ma; Xunming Ji; Yumin Luo
Journal:  Br J Pharmacol       Date:  2019-11-08       Impact factor: 8.739

Review 2.  Immune responses in stroke: how the immune system contributes to damage and healing after stroke and how this knowledge could be translated to better cures?

Authors:  Aditya Rayasam; Martin Hsu; Julie A Kijak; Lee Kissel; Gianna Hernandez; Matyas Sandor; Zsuzsanna Fabry
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3.  The contribution of antibiotics, pneumonia and the immune response to stroke outcome.

Authors:  Kyra J Becker; Dannielle Zierath; Allison Kunze; Leia Fecteau; Brian Lee; Shawn Skerrett
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Review 4.  Inflammatory Responses After Ischemic Stroke.

Authors:  Jonathan Howard DeLong; Sarah Naomi Ohashi; Kevin Charles O'Connor; Lauren Hachmann Sansing
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Review 5.  Emerging Role of Immunity in Cerebral Small Vessel Disease.

Authors:  Ying Fu; Yaping Yan
Journal:  Front Immunol       Date:  2018-01-25       Impact factor: 7.561

Review 6.  Point-of-Care-Testing in Acute Stroke Management: An Unmet Need Ripe for Technological Harvest.

Authors:  Dorin Harpaz; Evgeni Eltzov; Raymond C S Seet; Robert S Marks; Alfred I Y Tok
Journal:  Biosensors (Basel)       Date:  2017-08-03

Review 7.  Autoimmunity After Ischemic Stroke and Brain Injury.

Authors:  Ehsan Javidi; Tim Magnus
Journal:  Front Immunol       Date:  2019-04-02       Impact factor: 7.561

8.  Immune markers are associated with cognitive performance in a multiethnic cohort: The Northern Manhattan Study.

Authors:  Mitchell S V Elkind; Michelle Moon; Tatjana Rundek; Clinton B Wright; Ken Cheung; Ralph L Sacco; Mady Hornig
Journal:  Brain Behav Immun       Date:  2021-07-25       Impact factor: 19.227

9.  Brain ureido degenerative protein modifications are associated with neuroinflammation and proteinopathy in Alzheimer's disease with cerebrovascular disease.

Authors:  Xavier Gallart-Palau; Aida Serra; Benjamin Sian Teck Lee; Xue Guo; Siu Kwan Sze
Journal:  J Neuroinflammation       Date:  2017-09-02       Impact factor: 8.322

Review 10.  Biomarkers for acute diagnosis and management of stroke in neurointensive care units.

Authors:  Olena Y Glushakova; Alexander V Glushakov; Emmy R Miller; Alex B Valadka; Ronald L Hayes
Journal:  Brain Circ       Date:  2016-03-11
  10 in total

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