| Literature DB >> 26195191 |
Meili Li1,2, Si Jiang1, Jinlin Wang1, Chuncong Mo1, Zhancheng Zeng1, Yanjia Yang1, Chunke Chen1, Xiaowei Li1, Wei Cui1, Jinlu Huang3, Tao Peng2, Mingsheng Cai4,5.
Abstract
The pseudorabies virus (PRV) UL31 protein (pUL31) is a homologue of the herpes simplex virus 1 pUL31, which is a multifunctional protein that is important for HSV-1 infection. However, little is known concerning the subcellular localization signal of PRV UL31. Here, by transfection with a series of PRV UL31 deletion mutants fused to an enhanced yellow fluorescent protein (EYFP) gene, a bipartite nuclear localization signal (NLS) and a PY motif NLS of UL31 were identified and mapped to amino acids (aa) 4 to 20 (RRRLLRRKSSAARRKTL) and aa 21 to 34 (TRAARDRYAPYFAY), respectively. Additionally, the predicted nuclear export signal (NES) was shown to be nonfunctional. Taken together, this information opens up new avenues for investigating the biological functions of UL31 during PRV infection.Entities:
Keywords: Nuclear export signal (NES); Nuclear localization signal (NLS); PRV UL31
Mesh：
Substances：
Year: 2015 PMID： 26195191 DOI： 10.1007/s00705-015-2527-7
Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574