B-P Jiann1,2, Y-J Huang3,4. 1. Division of Basic Medical Research, Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan. 2. School of Medicine, National Yang-Ming University, Taipei, Taiwan. 3. Human Clinical Trial and Subject Protection Center, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan. 4. Graduate School of Human Sexuality, Shu-Te University, Kaohsiung, Taiwan.
Abstract
INTRODUCTION: There are limited data on the treatment satisfaction with dapoxetine in patients with premature ejaculation (PE). AIMS: We aimed to evaluate the treatment satisfaction, effectiveness and safety of dapoxetine for PE patients. METHODS: Subjects received dapoxetine (30 mg or 60 mg) alone or in combination with a phosphodiesterase type 5 inhibitor, if concurrent with erectile dysfunction for more than 4 weeks in clinical practice. Main outcome measures include Clinical Global Impression of Change (CGIC) and Clinical Global Impression of Satisfaction (CGIS). RESULTS: From March 2014 to January 2015, a total of 286 PE patients received dapoxetine treatment in this study, with 137 (47.9%) patients diagnosed with lifelong PE and 149 (52.1%) patients diagnosed with acquired PE. At the final follow-up visit, the mean intravaginal ejaculatory latency time (an increase of 3.4 min) and mean score of Premature Ejaculation Diagnostic Tool (a decrease of -5.0) improved significantly from baseline, and the satisfaction rate and response rate to dapoxetine treatment were 45.0% and 74.6%, respectively. Satisfaction with dapoxetine treatment was highly correlated with treatment response, and might be improved by scheduled follow-up visits and escalation to a higher dose. Subjects with diabetes mellitus (DM) reported a lower treatment response than those without DM. Treatment-emergent adverse event (TEAEs) occurred in 47.7% of patients, but no serious TEAEs were reported. CONCLUSION: Our real-world data highlight the effectiveness of dapoxetine and the importance of follow-up visits for the treatment of PE. Half of PE patients were not satisfied with dapoxetine treatment, which reflects an unmet need of present approach or an unrealistic expectation from PE patients.
INTRODUCTION: There are limited data on the treatment satisfaction with dapoxetine in patients with premature ejaculation (PE). AIMS: We aimed to evaluate the treatment satisfaction, effectiveness and safety of dapoxetine for PE patients. METHODS: Subjects received dapoxetine (30 mg or 60 mg) alone or in combination with a phosphodiesterase type 5 inhibitor, if concurrent with erectile dysfunction for more than 4 weeks in clinical practice. Main outcome measures include Clinical Global Impression of Change (CGIC) and Clinical Global Impression of Satisfaction (CGIS). RESULTS: From March 2014 to January 2015, a total of 286 PE patients received dapoxetine treatment in this study, with 137 (47.9%) patients diagnosed with lifelong PE and 149 (52.1%) patients diagnosed with acquired PE. At the final follow-up visit, the mean intravaginal ejaculatory latency time (an increase of 3.4 min) and mean score of Premature Ejaculation Diagnostic Tool (a decrease of -5.0) improved significantly from baseline, and the satisfaction rate and response rate to dapoxetine treatment were 45.0% and 74.6%, respectively. Satisfaction with dapoxetine treatment was highly correlated with treatment response, and might be improved by scheduled follow-up visits and escalation to a higher dose. Subjects with diabetes mellitus (DM) reported a lower treatment response than those without DM. Treatment-emergent adverse event (TEAEs) occurred in 47.7% of patients, but no serious TEAEs were reported. CONCLUSION: Our real-world data highlight the effectiveness of dapoxetine and the importance of follow-up visits for the treatment of PE. Half of PE patients were not satisfied with dapoxetine treatment, which reflects an unmet need of present approach or an unrealistic expectation from PE patients.
Authors: Hyun Jun Park; Nam Cheol Park; Tae Nam Kim; Seung Ryong Baek; Kyung Min Lee; Sangmin Choe Journal: Sex Med Date: 2017-04-05 Impact factor: 2.491
Authors: Deok Ha Seo; Seong Uk Jeh; See Min Choi; Sung Chul Kam; Sae Woong Kim; Dae Yul Yang; Du Geon Moon; Sang Kuk Yang; Ki Ha Moon; Jae Seog Hyun Journal: World J Mens Health Date: 2016-12-22 Impact factor: 5.400