Dagfinn Matre1, Li Hu2, Leif A Viken1,3, Ingri B Hjelle1,4, Monica Wigemyr1,5,4, Stein Knardahl1, Trond Sand3,6, Kristian Bernhard Nilsen1,3,5. 1. National Institute of Occupational Health, Department of Work Psychology and Physiology, Oslo, Norway. 2. Key Laboratory of Cognition and Personality (Ministry of Education) and School of Psychology, Southwest University, Chongqing, China. 3. Norwegian University of Science and Technology, Department of Neuroscience, Trondheim, Norway. 4. Norwegian University of Life Sciences, Ås, Norway. 5. Oslo University Hospital - Ullevål, Department of Neurology, Section for Clinical Neurophysiology, Norway. 6. Department of Neurology and Clinical Neurophysiology, St. Olavs Hospital, Trondheim, Norway.
Abstract
STUDY OBJECTIVES: Sleep restriction (SR) has been hypothesized to sensitize the pain system. The current study determined whether experimental sleep restriction had an effect on experimentally induced pain and pain-elicited electroencephalographic (EEG) responses. DESIGN: A paired crossover study. INTERVENTION: Pain testing was performed after 2 nights of 50% SR and after 2 nights with habitual sleep (HS). SETTING: Laboratory experiment at research center. PARTICIPANTS: Self-reported healthy volunteers (n = 21, age range: 18-31 y). MEASUREMENTS AND RESULTS: Brief high-density electrical stimuli to the forearm skin produced pinprick-like pain. Subjective pain ratings increased after SR, but only in response to the highest stimulus intensity (P = 0.018). SR increased the magnitude of the pain-elicited EEG response analyzed in the time-frequency domain (P = 0.021). Habituation across blocks did not differ between HS and SR. Event-related desynchronization (ERD) was reduced after SR (P = 0.039). Pressure pain threshold of the trapezius muscle region also decreased after SR (P = 0.017). CONCLUSION: Sleep restriction (SR) increased the sensitivity to pressure pain and to electrically induced pain of moderate, but not low, intensity. The increased electrical pain could not be explained by a difference in habituation. Increased response magnitude is possibly related to reduced processing within the somatosensory cortex after partial SR.
STUDY OBJECTIVES: Sleep restriction (SR) has been hypothesized to sensitize the pain system. The current study determined whether experimental sleep restriction had an effect on experimentally induced pain and pain-elicited electroencephalographic (EEG) responses. DESIGN: A paired crossover study. INTERVENTION: Pain testing was performed after 2 nights of 50% SR and after 2 nights with habitual sleep (HS). SETTING: Laboratory experiment at research center. PARTICIPANTS: Self-reported healthy volunteers (n = 21, age range: 18-31 y). MEASUREMENTS AND RESULTS: Brief high-density electrical stimuli to the forearm skin produced pinprick-like pain. Subjective pain ratings increased after SR, but only in response to the highest stimulus intensity (P = 0.018). SR increased the magnitude of the pain-elicited EEG response analyzed in the time-frequency domain (P = 0.021). Habituation across blocks did not differ between HS and SR. Event-related desynchronization (ERD) was reduced after SR (P = 0.039). Pressure pain threshold of the trapezius muscle region also decreased after SR (P = 0.017). CONCLUSION: Sleep restriction (SR) increased the sensitivity to pressure pain and to electrically induced pain of moderate, but not low, intensity. The increased electrical pain could not be explained by a difference in habituation. Increased response magnitude is possibly related to reduced processing within the somatosensory cortex after partial SR.
Authors: Piotr J Durka; Jarosław Zygierewicz; Hubert Klekowicz; Józef Ginter; Katarzyna J Blinowska Journal: IEEE Trans Biomed Eng Date: 2004-07 Impact factor: 4.538
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